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      rhBMP-2의 작용기전과 구강악안면 영역의 골재생을 위한 rhBMP-2의 활용

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      https://www.riss.kr/link?id=A100290185

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      다국어 초록 (Multilingual Abstract)

      To overcome shortcoming of autogeneous, allogenic, xenogenic and alloplastic bone grafts, various growth factors related to bone regeneration have been identified and developed. Among them, rhBMP 2 is regarded as the most potent osteoinductive growth ...

      To overcome shortcoming of autogeneous, allogenic, xenogenic and alloplastic bone grafts, various growth factors related to bone regeneration have been identified and developed. Among them, rhBMP 2 is regarded as the most potent osteoinductive growth factor and it can trigger the differentiation of mesenchymal stem cells to osteogenic cells for accelerated new bone formation And several commercial products of rhBMP 2 are available in Korea. It is applied to maxillary sinus augmentation, guided bone regeneration and preservation of extraction socket. In this review, the development, action mechanism and clinical applications of rhBMP 2 will be described.

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      목차 (Table of Contents)

      • ABSTRACT
      • Ⅰ. 개발 과정과 작용기전
      • Ⅱ. BMP 전달체(carrier)
      • Ⅲ. 치과에서의 임상적용
      • 참고문헌
      • ABSTRACT
      • Ⅰ. 개발 과정과 작용기전
      • Ⅱ. BMP 전달체(carrier)
      • Ⅲ. 치과에서의 임상적용
      • 참고문헌
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      참고문헌 (Reference) 논문관계도

      1 Yano K, "et al : Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing" J Bone Miner Metab 27 : 355 ~ 363 , 2000

      2 Carragee EJ, "Weiner BK : A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery : emerging safety concerns and lessons learned" Spine J 11 : 471 ~ 491 , 2011

      3 Kim RY, "The effect of dose on rhBMP-2 signaling, delivered via collagen sponge, on osteoclast activation and in vivo bone resorption." Biomaterilas 35 : 1869 ~ 1881 , 2014

      4 Kim IS, "Promising efficacy of Escherichia coli recombinant human bone morphogenetic protein-2in collagen sponge for ectopic and orthotopic bone formation and comparison with mammalian cell recombinant human bone morphogenetic protein-2" Tissue Eng Part A 17 : 337 ~ 348 , 2011

      5 Triplett RG, "Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation" J Oral Maxillofac Surg 67 : 1947 ~ 1960 , 2009

      6 Wozney JM, "Novel regulators of bone formation: molecular clones and activities" Science 242 : 1528 ~ 1534 , 1988

      7 von Arx T, "Lateral ridge augmentation using different bone fillers and barrier membrane application. A histologic and histomorphometric pilot study in the canine mandible" Clin Oral Implants Res 12 : 260 ~ 269 , 2001

      8 Gutwald R, "Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. : An in vivo study on sheep" J Craniomaxillofac Surg 38 : 571 ~ 579 , 2010

      9 Bessho K, "Iizuka T : Bone induction by Escherichia coli-derived recombinant human bone morphogenetic protein-2 compared with Chinese hamster ovary cell-derived recombinant human bone morphogenetic protein-2" Br J Oral Maxillofac Surg 38 : 645 ~ 649 , 2000

      10 Chiapasco M, "Fresh Frozen versus Autogenous Iliac Bone for the Rehabilitation of the Extremely Atrophic Maxilla with Onlay Grafts and Endosseous Implants: Preliminary Results of a Prospective Comparative Study" Clin Implant Dent Relat Res , 2013

      1 Yano K, "et al : Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing" J Bone Miner Metab 27 : 355 ~ 363 , 2000

      2 Carragee EJ, "Weiner BK : A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery : emerging safety concerns and lessons learned" Spine J 11 : 471 ~ 491 , 2011

      3 Kim RY, "The effect of dose on rhBMP-2 signaling, delivered via collagen sponge, on osteoclast activation and in vivo bone resorption." Biomaterilas 35 : 1869 ~ 1881 , 2014

      4 Kim IS, "Promising efficacy of Escherichia coli recombinant human bone morphogenetic protein-2in collagen sponge for ectopic and orthotopic bone formation and comparison with mammalian cell recombinant human bone morphogenetic protein-2" Tissue Eng Part A 17 : 337 ~ 348 , 2011

      5 Triplett RG, "Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation" J Oral Maxillofac Surg 67 : 1947 ~ 1960 , 2009

      6 Wozney JM, "Novel regulators of bone formation: molecular clones and activities" Science 242 : 1528 ~ 1534 , 1988

      7 von Arx T, "Lateral ridge augmentation using different bone fillers and barrier membrane application. A histologic and histomorphometric pilot study in the canine mandible" Clin Oral Implants Res 12 : 260 ~ 269 , 2001

      8 Gutwald R, "Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. : An in vivo study on sheep" J Craniomaxillofac Surg 38 : 571 ~ 579 , 2010

      9 Bessho K, "Iizuka T : Bone induction by Escherichia coli-derived recombinant human bone morphogenetic protein-2 compared with Chinese hamster ovary cell-derived recombinant human bone morphogenetic protein-2" Br J Oral Maxillofac Surg 38 : 645 ~ 649 , 2000

      10 Chiapasco M, "Fresh Frozen versus Autogenous Iliac Bone for the Rehabilitation of the Extremely Atrophic Maxilla with Onlay Grafts and Endosseous Implants: Preliminary Results of a Prospective Comparative Study" Clin Implant Dent Relat Res , 2013

      11 Martuscelli R, "Five-year outcome of bone remodelling around implants in the maxillary sinus: assessment of differences between implants placed in autogenous inlay bone blocks and in ungrafted maxilla" Int J Oral Maxillofac Surg , 2014

      12 Jung RE, "Effect of rhBMP-2 on guided bone regeneration in humans" Clin Oral Implants Res 14 : 556 ~ 568 , 2003

      13 Bignon A, "Effect of micro-and macroporosity of bone substitutes on their mechanical properties and cellular response" Journal of Materials Science : Materials in Medicine 14 : 1089 ~ 1097 , 2003

      14 Carreira AC, "Bone morphogenetic proteins: facts, challenges, and future perspectives" J Dent Res 93 : 335 ~ 345 , 2014

      15 Urist MR, "Bone formation by autoinduction" Science 150 : 893 ~ 899 , 1965

      16 de Lange GL, "A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model" Oral Surg Oral Med Oral Pathol Oral Radiol 117 : 8 ~ 22 , 2014

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