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      KCI등재 SCOPUS SCIE

      Effect of ankaferd blood stopper in experimental peritoneal adhesion model

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      https://www.riss.kr/link?id=A101864313

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      다국어 초록 (Multilingual Abstract)

      Purpose: Ankaferd Blood Stopper (ABS) is an herbal extract attained from 5 different plants. It has the therapeutic potential to be used for the management of external hemorrhage and controlling gastrointestinal bleedings. To date, the safety of ABS f...

      Purpose: Ankaferd Blood Stopper (ABS) is an herbal extract attained from 5 different plants. It has the therapeutic potential to be used for the management of external hemorrhage and controlling gastrointestinal bleedings. To date, the safety of ABS for intraperitoneal usage is not clear. In this study, we investigated the effectiveness and safety of using intraperitoneal ABS in an experimental peritoneal adhesion model.
      Methods: Twenty-four male Wistar Albino rats were used in the study. The rats were randomly divided into 3 groups: saline, ABS, and control. On the 10th day, all rats were euthanized. The adhesions were evaluated by Nair’s macroscopic adhesion classification, and pathologically evaluated with Zühlke’s microscopic adhesion classification.
      Results: A macroscopic and microscopic comparison between the ABS and saline groups did not show any differences but both the ABS and saline groups were superior when compared to the control group.
      Conclusion: ABS was found equally effective with saline on the abdominal adhesions and to no effect on postoperative adhesion formation.

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      목차 (Table of Contents)

      • INTRODUCTION
      • METHODS
      • RESULTS
      • DISCUSSION
      • REFERENCES
      • INTRODUCTION
      • METHODS
      • RESULTS
      • DISCUSSION
      • REFERENCES
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      참고문헌 (Reference)

      1 Turhan N., "Topical Ankaferd Blood Stopper administration to bleeding gastrointestinal carcinomas decreases tumor vascularization" 104 : 2874-2877, 2009

      2 Rasa K., "The effect of methylene blue on peritoneal adhesion formation" 13 : 108-111, 2002

      3 Davey AK., "Surgical adhesions : a timely update, a great challenge for the future" 14 : 15-22, 2007

      4 Shorbagi A., "Successful management of a difficult case of radiation proctopathy with Ankaferd BloodStopper : a novel indication(with video)" 72 : 666-667, 2010

      5 Nair SK., "Role of proteolytic enzyme in the prevention of postoperative intraperitoneal adhesions" 108 : 849-853, 1974

      6 Kluger Y., "Reduction in formation of peritoneal adhesions by methylene blue in rats : a dose response study" 166 : 568-571, 2000

      7 Elkelani OA., "Prevention of adhesions with crystalloids during laparoscopic surgery in mice" 9 : 447-452, 2002

      8 Tarhan OR., "Pentoxifylline, a methyl xanthine derivative, reduces peritoneal adhesions and increases peritoneal fibrinolysis in rats" 209 : 24955-, 2006

      9 Zuhlke HV., "Pathophysiology and classification of adhesions" 1009-1016, 1990

      10 Kilic O., "Haemostatic role and histopathological effects of a new haemostatic agent in a rat bladder haemorrhage model : an experimental trial" 105 : 1722-1725, 2010

      1 Turhan N., "Topical Ankaferd Blood Stopper administration to bleeding gastrointestinal carcinomas decreases tumor vascularization" 104 : 2874-2877, 2009

      2 Rasa K., "The effect of methylene blue on peritoneal adhesion formation" 13 : 108-111, 2002

      3 Davey AK., "Surgical adhesions : a timely update, a great challenge for the future" 14 : 15-22, 2007

      4 Shorbagi A., "Successful management of a difficult case of radiation proctopathy with Ankaferd BloodStopper : a novel indication(with video)" 72 : 666-667, 2010

      5 Nair SK., "Role of proteolytic enzyme in the prevention of postoperative intraperitoneal adhesions" 108 : 849-853, 1974

      6 Kluger Y., "Reduction in formation of peritoneal adhesions by methylene blue in rats : a dose response study" 166 : 568-571, 2000

      7 Elkelani OA., "Prevention of adhesions with crystalloids during laparoscopic surgery in mice" 9 : 447-452, 2002

      8 Tarhan OR., "Pentoxifylline, a methyl xanthine derivative, reduces peritoneal adhesions and increases peritoneal fibrinolysis in rats" 209 : 24955-, 2006

      9 Zuhlke HV., "Pathophysiology and classification of adhesions" 1009-1016, 1990

      10 Kilic O., "Haemostatic role and histopathological effects of a new haemostatic agent in a rat bladder haemorrhage model : an experimental trial" 105 : 1722-1725, 2010

      11 Holmdahl L., "Experimental models for quantitative studies on adhesion formation in rats and rabbits" 26 : 248-256, 1994

      12 Aysan E., "Experimental adhesion model : effect of viscosities of fluids put in the peritoneal cavity on preventing peritoneal adhesions" 56 : 349-354, 2007

      13 Kurt M., "Endoscopic application of ankaferd blood stopper as a novel experimental treatment modality for upper gastrointestinal bleeding : a case report" 103 : 21568-, 2008

      14 Gungor G., "Efficacy of ankaferd blood stopper application on non-variceal upper gastrointestinal bleeding" 4 : 556-560, 2012

      15 Isler SC., "Effects of folk medicinal plant extract Ankaferd Blood Stopper on early bone healing" 18 : 409-414, 2010

      16 Larsson B., "Effect of intraperitoneal instillation of 32% dextran 70 on postoperative adhesion formation after tubal surgery" 64 : 437-441, 1985

      17 Muller SA., "Effect of intraperitoneal antiadhesive fluids in a rat peritonitis model" 138 : 286-290, 2003

      18 Kalayci MU., "Effect of ankaferd blood stopper on hemosta sis and histopathological score in experimental liver injury" 111 : 183-188, 2010

      19 Comert M., "Does intraabdominal use of Ankaferd Blood Stopper cause increased intraperitoneal adhesions?" 16 : 383-389, 2010

      20 Kandemir O., "Demon stration of the histopathological and immunohistochemical effects of a novel hemostatic agent, Ankaferd Blood Stopper, on vascular tissue in a rat aortic bleeding model" 5 : 110-, 2010

      21 Huri E., "Biphasic effects of ankaferd blood stopper on renal tubular apoptosis in the rat partial nephrectomy model representing distinct levels of hemorrhage" 31 : 864-868, 2010

      22 Tasdelen Fisgin N., "Antimicrobial activity of plant extract Ankaferd Blood Stopper" 80 : 48-50, 2009

      23 Holmdahl L., "Adhesions : pathogenesis and prevention-panel discussion and summary" 0 (0): 56-62, 1997

      24 Elkins TE., "Adhesion prevention by solutions of sodium carboxymethylcellulose in the rat. I" 41 : 926-928, 1984

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      학술지 이력

      학술지 이력
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      2006-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2005-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.39 0.21 0.97
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.73 0.56 0.328 0.06
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