의생물학 문헌에 보고된 후보 암표지자 정보추출시스템 개발 = Development of a System for Extracting the Information of Candidate Tumor Markers Reported in Biomedical Literatures

다국어 초록 (Multilingual Abstract)

Background : Since the human genome project was completed in 2003, there have been numerous
reports on cancer and related markers. This study was aimed to develop a system to extract automatically
information regarding the relationship between cancer and tumor markers from biomedical literatures.
Methods : Named entities of tumor markers were recognized by both a dictionary-based method
and machine learning technology of the support vector machine. Named entities of cancers were
recognized by the MeSH dictionary.
Results : Relational and filtering keywords were selected after annotating 160 abstracts from
PubMed. Relational information was extracted only when one of the relational keywords was in an
appropriate position along the parse tree of a sentence with both tumor marker and disease entities.
The performance of the system developed in this study was evaluated with another set of 77
abstracts. With the relational and filtering keyword used in the system, precision was 94.38% and
recall was 66.14%, while without the expert knowledge precision was 49.16% and recall was 69.29%.
Conclusions : We developed a system that can extract relational information between a tumor and
its markers by incorporating expert knowledge into the system. The system exploiting expert knowledge
would serve as a reference when developing another information extraction system in various
medical fields. (Korean J Lab Med 2008;28:79-87)

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