조혈모세포 이식 후 발생한 자가면역성 용혈성빈혈 1예 = A Case of Autoimmune Hemolytic Anemia Complicating Hematopoietic Cell Transplantation

다국어 초록 (Multilingual Abstract)

A 32-yr-old male diagnosed with myelodysplastic syndrome underwent an unmanipulated, unrelated,
HLA matched, peripheral blood stem cell transplantation. The patient and donor were both
blood type O, CcDEe. Twelve weeks post-transplantation, he developed acute autoimmune hemolytic
anemia (AIHA). He was transfused multiple times with washed O red cells. High-dose steroid therapy
was initiated and he underwent splenectomy; however, AIHA was refractory to therapy. The
patient was further treated with combined treatment modalities including immunosuppressive therapy
with mycophenolate mofetil and cyclosporine and three cycles of plasma exchange, and AIHA
responded to treatment. This is the third case of AIHA complicating hematopoietic stem cell transplantation
reported in Korea. Since AIHA is relatively common after hematopoietic stem cell transplantation,
accurate and timely diagnosis of the disease and treatment strategies with multiple modalities
are necessary. (Korean J Lab Med 2008;28:64-9)

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