항암제 전달을 위한 독소루비신이 충진된 핵/쉘 나노입자 = Doxorubicin-Loaded Core/Shell Nanoparticles for Anti-Cancer Drug Delivery

다국어 초록 (Multilingual Abstract)

Doxorubicin-loaded core/shell nanoparticles were prepared and characterized as a drug delivery system. The lipid core
is composed of lecithin and polymeric shell is composed of Pluronic (poly(ethylene oxide)-poly(propylene oxide)-
poly(ethylene oxide) triblock copolymer, F-68). Freeze-drying of doxorubicin-loaded lipid core was performed in the
F-68 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/shell nanoparticles. FE-SEM
(Field Emission-Scanning Electron Microscopy) was used to observe the morphology of core/shell nanoparticles and
electrophoretic light scattering was used to observe the particle size and zeta potential. Doxorubicin was loaded into
the core/shell nanoparticles by ionic interaction and sustained release of loaded doxorubicin was observed.

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