백서 모델에서 갑상선 절제술 후 Poloxamer/Alginate/CaCl₂ 유착방지제의 효과 = Anti-Adhesive Effect of Poloxamer/alginate/CaCl₂ after Thyroidectomy in a Rat Model

다국어 초록 (Multilingual Abstract)

This study was conducted to compare the effectiveness of Poloxamer/alginate/CaCl₂ for reducing adhesion after thyroidectomy
in a rat model. Tissue adhesion is one of the major causes of well known postsurgical complications,
including patient's pain, functional obstruction and difficult preoperative surgery. Several adhesion barriers have been
developed in the form of solution or membrane in an attempt to solve the postsurgical problems. However both types
of tissue barriers have some limitations in their practical applications. In order to overcome these problems, a temperature-
sensitive Poloxamer/alginate/CaCl₂ was prepared as an adhesion barrier. The sol-gel transition behavior was
measured using a viscometer. And in vitro gel stability test was performed. The anti-adhesion effect was evaluated using
a thyroidectomy model. Two week after surgery, the level of adhesion was graded from zero to two using a wholenumber
system. And also toxicity, inflammation and the adhesion prevention effect were evaluated. The LCST (lower
critical solution temperature) of the Poloxamer/Alginate/CaCl₂ was 25℃. The gel stability of Poloxamer was improved
by adding cross-linked sodium Alginate/CaCl₂. The adhesion grade was significantly lower in the experimental group
than in the control. From the results, Poloxamer/alginate/CaCl₂ is an excellent candidate material having highly effective
anti-adhesion, low inflammatory response, and non-toxicity for clinical applications as a tissue adhesion barrier gel.

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