Cu 전극 사이에 존재하는 항체 접합용 자성입자의 크기와 분포에 따른 자기저항 특성 연구

다국어 초록 (Multilingual Abstract)

For the development of antibody therapeutics, magnetoresistance (MR) characteristics according to the size and distribution of superparamagnetic magnetic beads (MBs) and magnetic nanoparticles (MNPs), each with surfaces functionalized by silanol and carboxyl groups with magnetite (Fe₃O₄) cores, were investigated. Particles of different sizes were placed within a 1 mm space in the center of a plastic tank that could contain up to 10 μl in volume. A magnetic field was applied to the tank in order to distribute the particles. The minimum MR value, MR ratio, and solution coercivity obtained from the voltage curve, measured according to the strength of the external magnetic field passing through the MBs solution, were 3.567 MΩ, 1.1%, and 400 Oe, respectively; for the MNPs solution, 0.245 MΩ, 50%, and 184 Oe, respectively. The MNPs solution containing 0.35 μm sized particles showed a much more sensitive change in MR properties than the MB solution with 1 μm sized particles. This phenomenon was analyzed to have been caused by the estimated split distance (ESD) created by the movement of different sized magnetic particles and whether a large or small number of estimated degree of solution pathway (EDSP) were created in response to an external magnetic field. It was discussed that these characteristics could potentially be used to control the function of various biomolecules, including antibodies conjugated to the surface of MNPs.

참고문헌 (Reference)

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13 최종구, "증류수 내 자성비드 용액의 자기장에 의존하는 자기저항 특성 연구" 한국자기학회 29 (29): 123-128, 2019

14 최종구, "생리식염수와 증류수에 담긴 자성나노입자와 자성비드들의 자기저항 특성 연구" 한국물리학회 69 (69): 883-888, 2019

15 "https://nanocomposix.com/collections/material-magnetite/products/biopure-magnetite-nanoparticles-pvp?variant=15906783264857"

16 "SiMAG-Silanol beads"

17 "SPHEROTM Magnetic Particles"