Observation of chitosan coated lipid nanoparticles with different lipid compositions under simulated <i>in vitro</i> digestion system

다국어 초록 (Multilingual Abstract)

<P><B>Abstract</B></P> <P>The effects of lipid composition and chitosan coating on lipid digestion ability were investigated using a simulated <I>in vitro</I> digestion system, including oral, gastric, and small intestine stages. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were prepared with only palm oil and the mixture of palm oil and medium-chain triglyceride (MCT) oil, respectively. Chitosan-coated SLNs (CS-SLNs) and NLCs (CS-NLCs) were prepared with a drop-wise method. CS-NLCs were more completely digested than the NLCs, while the NLCs showed higher free fatty acid release than SLNs. Chitosan coating increased the particle size of both SLNs and NLCs from 100.0 to 104.9 nm to 130.0 and 146.5 nm, respectively. Chitosan coating also increased the initial digestion rate of NLCs by modulating lipid droplet aggregation. But, chitosan coating showed little impact on the digestion of SLNs because SLNs did not strongly impact the lipid droplet aggregation state. These results have important implications for the fabrication of functional foods and beverages to achieve control of lipid digestion in the gastrointestinal tract.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Four lipid nanoparticles were prepared to compare the lipid digestion. </LI> <LI> The particles were subjected to an <I>in vitro</I> simulated digestive system and compared. </LI> <LI> NLC showed more rapid digestion than SLN due to the liquid lipid. </LI> <LI> Free fatty acid release profile of CS-SLN was almost same to that of SLN. </LI> <LI> CS-NLC showed greater free fatty acid release than NLC. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>