비용매 유도 상전이법을 이용한 혈액투석막의 제조 및 분리 특성 평가|RISS 상세보기

다국어 초록 (Multilingual Abstract)

Hemodialysis is one of the most common kidney replacement methods such askidney transplantation and peritoneal dialysis for patients with kidney disease such as renalfailure. In this study, a polymer solution containing polyethersulfone(PES) as the main rawmaterial and polyvinylpyrrolidone(PVP), a hydrophilic polymer, was prepared by using differenttypes of non-solvent when manufacturing hemodialysis membranes using the nonsolventinduced phase separation(NIPS) method. The characteristics of the manufacturedhemodialysis membrane were analyzed through ATR-FTIR and SEM, and the separationcharateristics of the hemodialysis membrane were evaluated by performing simulateddialysis using artificial blood and dialysate. As a result, the chemical structure of the manufacturedhemodialysis membranes did not change depending on the type of non-solvent,and in the case of the cross-sectional structure, a finger-like structure and a sponge structurewere confirmed according to the non-solvent. The maximum removal rate of toxicmaterials were Urea 56.97% and Creatinine 52.71%, and protein loss was less than 6%. Inaddition, cell viability was evaluated as up to 92.4%. The biocompatibility and functionalityof the hemodialysis membrane made of PES were confirmed.

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참고문헌 (Reference)

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