독활 메탄올 추출물과 그 분획의 항혈전 및 항산화 효과를 확인하기 위하여 ADP를 이용하여 혈소판 응집억제효과를 탐색하고 DPPH 및 ABTS-radical 소거능을 측정하여 항산화능을 측정하였다. 그 ...
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https://www.riss.kr/link?id=A76268371
2008
Korean
KCI등재
학술저널
357-362(6쪽)
9
0
상세조회0
다운로드국문 초록 (Abstract)
독활 메탄올 추출물과 그 분획의 항혈전 및 항산화 효과를 확인하기 위하여 ADP를 이용하여 혈소판 응집억제효과를 탐색하고 DPPH 및 ABTS-radical 소거능을 측정하여 항산화능을 측정하였다. 그 ...
독활 메탄올 추출물과 그 분획의 항혈전 및 항산화 효과를 확인하기 위하여 ADP를 이용하여 혈소판 응집억제효과를 탐색하고 DPPH 및 ABTS-radical 소거능을 측정하여 항산화능을 측정하였다. 그 결과 독활, 특히 EtOAc 분획은 ADP에 의해 유도된 혈소판응집과 트롬빈에 의한 혈소판 부착에 대하여 농도 의존적으로 저해효과를 나타내었으며, 높은 폴리페놀 함량과 가장 높은 라디칼 소거능을 통하여 독활의 항산화 효과를 확인하였다. 이상의 결과로 독활 EtOAc 분획의 높은 DPPH 및 ABTS radical 소거능이 항혈소판 효과에 영향을 미치는 것으로 사료된다.
다국어 초록 (Multilingual Abstract)
The dried roots of Aralia continentalis Kitagawa is known to have the potential for anti-inflammation and anti-rheumatic, but their effects on thrombosis are not clear. In this study, we evaluated the anti-platelet and antioxidative activities of A. c...
The dried roots of Aralia continentalis Kitagawa is known to have the potential for anti-inflammation and anti-rheumatic, but their effects on thrombosis are not clear. In this study, we evaluated the anti-platelet and antioxidative activities of A. continentalis Kitagawa. Methanol extract and its various fractions of A. continentalis Kitagawa inhibited ADP-induced platelet aggregation, and EtOAc fraction showed strongest inhibition in a concentration-dependent manner with a IC?? value of 217.7 ㎍/ml. Moreover, the EtOAc fraction contained 77.7% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 43.1% of 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging activity at 0.1 ㎎/ml. In addition, the methanol and EtOAc fraction dose-dependently inhibited thrombin-stimulated platelet adhesion to collagen or fibrinogen. Collectively, these results suggest that the polyphenol-rich EtOAc fraction from A. continentalis Kitagawa can reduce platelet hyperactivation by scavenging free radicals. Thus, the EtOAc fraction of A. continentalis Kitagawa is a potential source for inhibition of platelet-dependent thrombosis.
참고문헌 (Reference)
1 유미희, "생대추(풋대추) 과육 및 씨 추출물의 항산화 효과 및 항산화 성분" 한국식품과학회 38 (38): 128-134, 2006
2 최용민, "국내 시판되는 일부 다류 제품의 항산화 효과" 한국식품영양과학회지 32 (32): 723-727, 2003
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1 유미희, "생대추(풋대추) 과육 및 씨 추출물의 항산화 효과 및 항산화 성분" 한국식품과학회 38 (38): 128-134, 2006
2 최용민, "국내 시판되는 일부 다류 제품의 항산화 효과" 한국식품영양과학회지 32 (32): 723-727, 2003
3 Ancerewicz, J., "Structure-property relationships of trimetazidine derivatives and model compounds as potential antioxidants" 25 : 113-120, 1998
4 Tusuzynski, G. P, "Spectrophotometric quantitation of anchorage-dependent cell numbers using the bicinchoninic acid protein assay reagent" 184 : 189-191, 1990
5 Folin, O, "On phosphotungstic-phosphomolybdic compounds as color reagents" 12 : 239-249, 1912
6 Perry, L. M, "Medicinal plants of East and Southeast Asia: attributed properties and uses" MIT Press 620-, 1980
7 Longenecker, G. L., "Kinetics of ibuprofen effect on platelet and endothelial prostanoid release" 37 : 343-348, 1985
8 Han,W.S, "Isolation of the antimicrobial compounds from Aralia cordata Thunb. extract" 13 : 182-185, 2005
9 Kim, J. S., "Isolation of flavonoids from the leaves of Aralia continentalis" 26 : 239-243, 1995
10 Nguyen Hai Dang, "Inhibitory Constituents against Cyclooxygenases from Aralia cordata Thunb" 대한약학회 28 (28): 28-33, 2005
11 Tzeng, S. H., "Inhibition of platelet aggregation by some flavonoids" 64 : 91-100, 1991
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13 Durand, P, "In-vitro and ex-vivo inhibition of blood platelet aggregation by naftazone" 48 : 566-572, 1996
14 Veiga, A. B., "Fibrinogenolytic and procoagulant activities in the hemorrhagic syndrome caused by Lonomia obliqua caterpillars" 111 : 95-101, 2003
15 Mustard, J. F, "Factors influencing platelet function: adhesion, release and aggregation" 22 : 97-187, 1970
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17 Miwa, K., "Effect of aspirin in large doses on attacks of variant angina" 105 : 351-355, 1983
18 Lefevre, M., "Dietary fatty acids, hemostasis, and cardiovascular disease risk" 104 : 410-419, 2004
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21 Blois,M.S, "Antioxidant determinations by the use of a stable free radical" 181 : 1198-1200, 1958
22 Kim, J. S, "Antioxidant components from Aralia continentalis" 29 : 13-17, 1998
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작잠( Antheraea pernyi) arylphorin의 항체를 이용한 수종의 나비목 야생 견사곤충들 간의 면역학적 비교
Adenocarcinoma of Meibomian Glands and Moll Glands in the Eyelid of Canine
Properties of the Membrane-Bound NADH
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2021-01-01 | 평가 | 등재학술지 유지 (재인증) | ![]() |
2018-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2015-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2011-08-03 | 학술지명변경 | 외국어명 : Korean Journal of Life Science -> Journal of Life Science | ![]() |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | ![]() |
2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | ![]() |
2001-07-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.37 | 0.37 | 0.42 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.43 | 0.43 | 0.774 | 0.09 |