RISS 검색 - 국내학술지논문 상세보기

부가정보

다국어 초록 (Multilingual Abstract)

Background: An elevated serum sialic acid concentration has recently been shown to be a potent predictor of cardiovascular mortality in the general white population. Microalbuminuria has been shown to be a independent risk factor or predictor of diabetic nephropathy and macroangiopathy in NIDDM. Several studies have shown a elevated serum sialic acid concentrations in NIDDM patients compared with nondiabetic subjects and in IDDM patients with microalbuminuria and clinical proteinuria.
Methods : We studied 29 patients with NIDDM who had a normal urinary albumin excretion rate, 16 patients who had microalbuminuria, and 23 patients with clinical proteinuria. We also investigated sialic acid levels related to blood pressure, microalbuminuna, glycemic control, lipid analysis, serum sialic acid levels, and retinopathy.
Results :
1) This study shows that NIDDM patients with macroalbuminuna had significantly higher serum sialic acid concentrations than control group, normoalbummuria, and microalbuminuria group.(meand:SE : 90.41±5.6 vs. 69.7±3.8, 68.2±2.4 and 72.6±2.9mg/dl, p<0.05 respectively).
2) Multiple linear regression analysis showed that systolic blood pressure, duration of diabetes, diastolic blood pressure, triglyceride, ESR, and albumin excretion rate (AER) correlate independently with logarithmic serum sialic acid concentrations.
3) The presence or absence of diabetic retinopathy had no impact on serum sialic acid concentration.
Conclusions : This study shows that the serum sialic acid concentration is raised in NIDDM patients with macroalbuminuria. And there are no relationships between serum sialic acid and diabetic retinopathy. Further study is needed to confirm the mechanism of elevated serum sialic acid in NIDDM. And prospective studies are thought to be required to evaluate whether serum sialic acid concentration can be used as a predictor of microvascular and macrovascular complications in diabetes.