Spatio-temporal expression pattern and fasting response of follistatin gene in teleost Larimichthys crocea

다국어 초록 (Multilingual Abstract)

Follistatin is a multifunctional regulatory proteininvolved in numerous physiological activities. Tobetter understand its functions in Larimichthys crocea (L.crocea), the entire cDNA sequence of follistatin from L.
crocea was cloned, the transcript abundance of follistatinwas measured at different development stages and in differentgender. A fasting-refeeding protocol was also performedto correlate follistatin tissue expression withnutritional status in the juvenile stage of L. crocea. Theresults showed that follistatin transcripts were weaklydetected before gastrula stage (9 h post-fertilization; hpf),and at the highest level at myogenesis stage (15 hpf) and 30days after hatching (30 dah). In adult fish, follistatin transcriptswere observed in all the ten tissues examined andmost abundant in eye, gill, muscle, brain and intestine.
Moreover, the abundance of follistatin transcripts in mosttissues was influenced by the age and gender. Duringfasting and refeeding period, the regulatory response offollistatin in muscle, liver, gonad, spleen and brain of L.
crocea varied greatly. Altogether, these findings supportthe evidence that follistatin plays a profound role in theteleost development and that it is an indispensable factorfor the survival of teleosts when challenged with environmentalstresses like fasting.

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