Efficacy of ablative fractional CO₂ laser and bleomycin combination therapy on periungual viral warts = Efficacy of ablative fractional CO₂ laser and bleomycin combination therapy on periungual viral warts

다국어 초록 (Multilingual Abstract)

Background: The treatment of periungual viral warts is a therapeutic challenge. Result of various treatments can be ineffective and may cause various complications, including permanent nail changes, pain and scar formation.
Objectives: To investigate the efficacy and safety of a ablative fractional carbon dioxide laser and bleomycin combination therapy in the treatment of periungual warts.
Methods: Wart lesions were treated with prior ablative cabon dioxide fractional laser. Immediately after each fractional laser treatment, bleomycin(1U/mL) was applied on the lesions. The patients were treated every 2 weeks until elimination of the lesions.
Results: Twenty six lesions(68.4%) achieved a complete clearance. Three lesions(7.8%) had excellent partial response(>75% improvement). There were no recurrences of those warts that had achieved complete clearance during the follow-up period of 6 months. No significant long-term adverse effects were noted. Only one lesion showed postinflammatory hyperpigmentation, which resolved within 1 month, and five patients(29%) had localized moderate pain for 2 to 3 days after the treatment.
Conclusion: Combination therapy of ablative fractional laser and bleomycin is an effective and safe modality to treat periungual warts. Further large controlled studies are necessary.