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      肥滿細胞의 脫顆粒에 미치는 pH의 影響에 關하여 = The Effect of pH on Mast Cell Degranulation Induced by Compound 48/80

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      https://www.riss.kr/link?id=A19689963

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      This study was performed to investigate the effects of pH on the degranulation of mesenteric and peritoneal mast cells induced by compound 48/80 in vivo and in vitro, and to determine the optimal dosage of compound 48/80 for the mast cell degranulation in various pH.
      Results were as following:
      1. In vivo study using mesenteric mast cells : the effect of compound 48/80(1㎍/ml) on mast cells was markedly increased in pH 7.8.
      2. In vitro study using peritoneal mast cells: the onset time of degranulation of mast cell induced by compound 48/80(0.33㎍/ml) was shorter in pH 7.2 and 7.8 than those in pH 5.5, 6.4 and 8.5.
      Above results suggested that response of mast cell to compound 48/80 was rapidly degranulated in pH 7.2 and pH 7.8.
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      This study was performed to investigate the effects of pH on the degranulation of mesenteric and peritoneal mast cells induced by compound 48/80 in vivo and in vitro, and to determine the optimal dosage of compound 48/80 for the mast cell degranulatio...

      This study was performed to investigate the effects of pH on the degranulation of mesenteric and peritoneal mast cells induced by compound 48/80 in vivo and in vitro, and to determine the optimal dosage of compound 48/80 for the mast cell degranulation in various pH.
      Results were as following:
      1. In vivo study using mesenteric mast cells : the effect of compound 48/80(1㎍/ml) on mast cells was markedly increased in pH 7.8.
      2. In vitro study using peritoneal mast cells: the onset time of degranulation of mast cell induced by compound 48/80(0.33㎍/ml) was shorter in pH 7.2 and 7.8 than those in pH 5.5, 6.4 and 8.5.
      Above results suggested that response of mast cell to compound 48/80 was rapidly degranulated in pH 7.2 and pH 7.8.

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