RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      KCI등재 SCIE SCOPUS

      Novel genes in Human Asthma Based on a Mouse Model of Allergic Airway Inflammation and Human Investigations

      한글로보기

      https://www.riss.kr/link?id=A104757485

      • 0

        상세조회
      • 0

        다운로드
      서지정보 열기
      • 내보내기
      • 내책장담기
      • 공유하기
      • 오류접수

      부가정보

      다국어 초록 (Multilingual Abstract)

      Purpose:Based on a previous gene expression study in a mouse model of asthma, we selected 60 candidate genes and investigated their possible roles in human asthma. Methods: In these candidate genes, 90 SNPs were genotyped using MassARRAY technology f...

      Purpose:Based on a previous gene expression study in a mouse model of asthma, we selected 60 candidate genes and investigated their possible roles in human asthma.
      Methods: In these candidate genes, 90 SNPs were genotyped using MassARRAY technology from 311 asthmatic children and 360 healthy controls of the Hungarian (Caucasian) population. Moreover, gene expression levels were measured by RT PCR in the induced sputum of 13 asthmatics and 10 control individuals. t-tests, chi-square tests, and logistic regression were carried out in order to assess associations of SNP frequency and expression level with asthma. Permutation tests were performed to account for multiple hypothesis testing.
      Results: The frequency of 4 SNPs in 2 genes differed significantly between asthmatic and control subjects: SNPs rs2240572, rs2240571, rs3735222 in gene SCIN, and rs32588 in gene PPARGC1B. Carriers of the minor alleles had reduced risk of asthma with an odds ratio of 0.64 (0.51-0.80; P=7×10-5) in SCIN and 0.56 (0.42-0.76; P=1.2×10-4) in PPARGC1B. The expression levels of SCIN, PPARGC1B and ITLN1 genes were significantly lower in the sputum of asthmatics.
      Conclusions: Three potentially novel asthma-associated genes were identified based on mouse experiments and human studies.

      더보기

      참고문헌 (Reference)

      1 Tsitsiou E, "Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma" 129 : 95-103, 2012

      2 Braman SS, "The global burden of asthma" 130 : 4S-12S, 2006

      3 Bierbaum S, "The genetics of bronchial asthma in children" 101 : 1369-1375, 2007

      4 Nagy A, "The development of asthma in children infected with Chlamydia pneumoniae is dependent on the modifying effect of mannose-binding lectin" 112 : 729-734, 2003

      5 Karolchik D, "The UCSC Table Browser data retrieval tool" 32 : D493-D496, 2004

      6 Davis CW, "Regulated airway goblet cell mucin secretion" 70 : 487-512, 2008

      7 Park SJ, "Peroxisome proliferator-activated receptor gamma as a novel therapeutic target in asthma" 45 : 1-8, 2008

      8 Holgate ST, "Pathogenesis of asthma" 38 : 872-897, 2008

      9 Lee KS, "PPAR-gamma modulates allergic inflammation thro-ugh up-regulation of PTEN" 19 : 1033-1035, 2005

      10 Di Valentin E, "New asthma biomarkers: lessons from murine models of acute and chronic asthma" 296 : L185-L197, 2009

      1 Tsitsiou E, "Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma" 129 : 95-103, 2012

      2 Braman SS, "The global burden of asthma" 130 : 4S-12S, 2006

      3 Bierbaum S, "The genetics of bronchial asthma in children" 101 : 1369-1375, 2007

      4 Nagy A, "The development of asthma in children infected with Chlamydia pneumoniae is dependent on the modifying effect of mannose-binding lectin" 112 : 729-734, 2003

      5 Karolchik D, "The UCSC Table Browser data retrieval tool" 32 : D493-D496, 2004

      6 Davis CW, "Regulated airway goblet cell mucin secretion" 70 : 487-512, 2008

      7 Park SJ, "Peroxisome proliferator-activated receptor gamma as a novel therapeutic target in asthma" 45 : 1-8, 2008

      8 Holgate ST, "Pathogenesis of asthma" 38 : 872-897, 2008

      9 Lee KS, "PPAR-gamma modulates allergic inflammation thro-ugh up-regulation of PTEN" 19 : 1033-1035, 2005

      10 Di Valentin E, "New asthma biomarkers: lessons from murine models of acute and chronic asthma" 296 : L185-L197, 2009

      11 Su AI, "Large-scale analysis of the human and mouse transcriptomes" 99 : 4465-4470, 2002

      12 Tölgyesi G, "Involvement of TNFalpha -308A promoter polymorphism in the development of asthma in children infected with Chlamydophila pneumoniae" 60 : 543-548, 2006

      13 "International HapMap Project" International HapMap Project

      14 Yanai I, "Incongruent expression profiles between human and mouse orthologous genes suggest widespread neutral evolution of transcription control" 8 : 15-24, 2004

      15 Ungvári I, "Implication of BIRC5 in asthma pathogenesis" 24 : 293-301, 2012

      16 Karp CL, "Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma" 1 : 221-226, 2000

      17 Barrett JC, "Haploview: analysis and visualization of LD and haplotype maps" 21 : 263-265, 2005

      18 Song KH, "Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis" 43 : 117-125, 2006

      19 Tsaparas P, "Global similarity and local divergence in human and mouse gene co-expression networks" 6 : 70-, 2006

      20 Lee SH, "Genetic effect of single-nucleotide polymorphisms in the PPARGC1B gene on airway hyperreactivity in asthmatic patients" 41 : 1533-1544, 2011

      21 Tölgyesi G, "Gene expression profiling of experimental asthma reveals a possible role of paraoxonase-1 in the disease" 21 : 967-975, 2009

      22 Jordan IK, "Evolutionary significance of gene expression divergence" 345 : 119-126, 2005

      23 Ungvári I, "Evaluation of a partial genome screening of two asthma susceptibility regions using bayesian network based bayesian multilevel analysis of relevance" 7 : e33573-, 2012

      24 Zimmermann N, "Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis" 111 : 1863-1874, 2003

      25 Vercelli D, "Discovering susceptibility genes for asthma and allergy" 8 : 169-182, 2008

      26 Kuhn A, "Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package ‘annotationTools’" 9 : 26-, 2008

      27 Strand AD, "Conservation of regional gene expression in mouse and human brain" 3 : e59-, 2007

      28 Jordan IK, "Conservation and coevolution in the scale-free human gene coexpression network" 21 : 2058-2070, 2004

      29 Nagy A, "Chlamydophila pneumoniae infection status is dependent on the subtypes of asthma and allergy" 28 : 58-63, 2007

      30 Ungvári I, "CCR5 Delta 32 mutation, Mycoplasma pneumoniae infection, and asthma" 119 : 1545-1547, 2007

      31 Ehre C, "Barrier role of actin filaments in regulated mucin secretion from airway goblet cells" 288 : C46-C56, 2005

      32 Lemanske RF Jr, "Asthma: clinical expression and molecular mechanisms" 125 : S95-S102, 2010

      33 Weiss ST, "Asthma genetics and genomics 2009" 19 : 279-282, 2009

      34 Finkelman FD, "Advances in asthma, allergy mechanisms, and genetics in 2006" 120 : 544-550, 2007

      35 Bush WS, "A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility" 12 : 335-340, 2011

      더보기

      동일학술지(권/호) 다른 논문

      분석정보

      View

      상세정보조회

      0

      Usage

      원문다운로드

      0

      대출신청

      0

      복사신청

      0

      EDDS신청

      0

      동일 주제 내 활용도 TOP

      더보기

      주제

      연도별 연구동향

      연도별 활용동향

      연관논문

      연구자 네트워크맵

      공동연구자 (7)

      유사연구자 (20) 활용도상위20명

      인용정보 인용지수 설명보기

      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2013-10-01 평가 등재학술지 선정 (기타) KCI등재
      2012-01-01 평가 등재후보학술지 유지 (기타) KCI등재후보
      2011-01-01 평가 등재후보 1차 FAIL (등재후보1차) KCI등재후보
      2010-07-14 학회명변경 한글명 : 대한알레르기학회 -> 대한천식알레르기학회
      영문명 : The Korean Academy Of Asthma And Allergy -> The Korean Academy of Asthma, Allergy and Clinical Immunology
      KCI등재후보
      2009-01-01 평가 SCOPUS 등재 (신규평가) KCI등재후보
      더보기

      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 2.43 0.8 1.86
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.55 1.38 0.89 0.15
      더보기

      이 자료와 함께 이용한 RISS 자료

      나만을 위한 추천자료

      해외이동버튼