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스콜라Mylabris phalerata (MP) is an insect that has been used for the treatment of cancer in oriental medicine. To evaluate the anticancer activity of Mylabris phalerata, We measured the cytotoxicity of Mylabris phalerata solvent fractions such as MC, EA, B...
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RISS 인기검색어
반묘 BuOH층의 U937세포주에 대한 apoptosis유도 효과 = Effect of Butanol Fraction of Mylabris phalerata on Induction of Apoptosis in U937 cells
한글로보기https://www.riss.kr/link?id=A100386384
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2001
-
작성언어
-
- 주제어
-
KDC
518
-
등재정보
KCI등재
-
자료형태
학술저널
- 발행기관 URL
-
수록면
484-490(7쪽)
- 제공처
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
Mylabris phalerata (MP) is an insect that has been used for the treatment of cancer in oriental medicine. To evaluate the anticancer activity of Mylabris phalerata, We measured the cytotoxicity of Mylabris phalerata solvent fractions such as MC, EA, BuOH and residual layers on U937, human monocytic leukemia cells. Of those fractions BuOH layer of Mylabris phalerata was the moat effective with IC50 of 140 μg/ml. It effectively caused DNA fragmentation from the concentration of 50μg/ml, showed apoptotic nucleus by tenet assay and expressed apototic portion stained by Annexin-V It also induced the activation of caspase-3 and cleavage of the substrate poly (ADP-ribose) polymerase (PARP). These results suggest BuOH layer of Mylabris phalerata exerts anticancer activity by induction of apoptosis via activation of caspase-3 protease.
Mylabris phalerata (MP) is an insect that has been used for the treatment of cancer in oriental medicine. To evaluate the anticancer activity of Mylabris phalerata, We measured the cytotoxicity of Mylabris phalerata solvent fractions such as MC, EA, BuOH and residual layers on U937, human monocytic leukemia cells. Of those fractions BuOH layer of Mylabris phalerata was the moat effective with IC50 of 140 μg/ml. It effectively caused DNA fragmentation from the concentration of 50μg/ml, showed apoptotic nucleus by tenet assay and expressed apototic portion stained by Annexin-V It also induced the activation of caspase-3 and cleavage of the substrate poly (ADP-ribose) polymerase (PARP). These results suggest BuOH layer of Mylabris phalerata exerts anticancer activity by induction of apoptosis via activation of caspase-3 protease.
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