실험동물에서 복합천연물(DW)의 지질 과산화 억제와 간섬유화 저해 효과 검색 = The Extracts from Natural Product Complex (DW) Suppress Lipid Peroxidation and Inhibit Liver Fibrosis (Cirrhosis) in Rats

다국어 초록 (Multilingual Abstract)

The chronic cholestasis induce to biliary liver fibrosis (cirrhosis) and the increased products of ROS(reactive oxygen species) cause to the liver damage. In this study; the antioxidant and antifibrotic effect of dried extracts of oriental medicine (DW) was investigated under the liver fibrotic (cirrhotic) condition. The female Sprague-Dawley rats were divided in 5 groups (Normal, Op-2, Op-4, OpDW-2, OpDW-4). Except for normal group, the rats were induced to biliary liver fibrosis (cirrhosis) by the operation of bile duct ligatiouscission (BDL/S) and were observed in 2 weeks or 4 weeks. And the prepared DW was treated p.o.2ml/day/rats in 2 weeks or 4 weeks for OpDW groups. At the time of sacrifice, the liver, kidney; spleen were weighed and the ratio of organ weighubody weight was calculated. The MDA, the hap and biochemical parameters (GOT GTP ALP t-bili) were measured in sera and liver tissue of rats. The histological change was observed on liver tissue. In the result, the hepatomegaly and spleenomegaly appeared in all BDL/S operated rats, and significantly lower liver weight was observed in OpDW-4 group compared with in Op-4 group (p