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      KCI등재 SCOPUS SCIE

      Antitumor Activities and Immunomodulatory Effects of Ginseng Neutral Polysaccharides in Combination with 5-Fluorouracil

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      https://www.riss.kr/link?id=A104510045

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      다국어 초록 (Multilingual Abstract)

      A neutral polysaccharide fraction (WGPN) prepared from Panax ginseng C.A. Meyer by hot water extraction and DEAE-cellulose chromatography was tested for its anticancer activity alone and in combination with 5-fluorouracil (5-FU) in Sarcoma-180 (S180) tumor-bearing mice by intragastric administration. WGPN alone inhibited S180 tumor growth in a bell-shaped dose–response curve, and the combination with 5-FU showed a synergistic effect. Studies of various immunological activities in S180-bearing mice revealed that WGPN stimulated the proliferation of lymphocytes, increased natural killer cell cytotoxicity, enhanced the phagocytosis and nitric oxide production by macrophages, and increased the level of tumor necrosis factor-α in serum. In combination with 5-FU, WGPN mitigated damage to the immune system caused by 5-FU in S180-bearing mice. These results suggest that WGPN might be a potential adjuvant for chemotherapeutic drugs.
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      A neutral polysaccharide fraction (WGPN) prepared from Panax ginseng C.A. Meyer by hot water extraction and DEAE-cellulose chromatography was tested for its anticancer activity alone and in combination with 5-fluorouracil (5-FU) in Sarcoma-180 (S180) ...

      A neutral polysaccharide fraction (WGPN) prepared from Panax ginseng C.A. Meyer by hot water extraction and DEAE-cellulose chromatography was tested for its anticancer activity alone and in combination with 5-fluorouracil (5-FU) in Sarcoma-180 (S180) tumor-bearing mice by intragastric administration. WGPN alone inhibited S180 tumor growth in a bell-shaped dose–response curve, and the combination with 5-FU showed a synergistic effect. Studies of various immunological activities in S180-bearing mice revealed that WGPN stimulated the proliferation of lymphocytes, increased natural killer cell cytotoxicity, enhanced the phagocytosis and nitric oxide production by macrophages, and increased the level of tumor necrosis factor-α in serum. In combination with 5-FU, WGPN mitigated damage to the immune system caused by 5-FU in S180-bearing mice. These results suggest that WGPN might be a potential adjuvant for chemotherapeutic drugs.

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      참고문헌 (Reference)

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      8 Xiao Fei Du, "Synergistic Immunostimulating Activity of Pidotimod and Red Ginseng Acidic Polysaccharide against Cyclophosphamide-induced Immunosuppression" 대한약학회 31 (31): 1153-1159, 2008

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      1 Harada S., "Two inverse pathways: the apoptosis and the multinucleated cell switched by the magnesium=zinc balance in irradiated sarcoma in vivo" 150 : 158-166, 1999

      2 Zhang X., "Total fractionation and characterization of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer" 3 : 544-552, 2009

      3 Talmadge JE, "The preclinical screening laboratory: evaluation of immunomodulatory and therapeutic properties of biological response modifiers" 70 : 171-182, 1986

      4 Sevag MG, "The isolation of the components of streptococcal nucleoproteins in serologically active form" 124 : 425-436, 1938

      5 Han SB, "The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis" 41 : 157-164, 1999

      6 Ishurd O., "The anti-cancer activity of polysaccharide prepared from Libyan dates (Phoenix dactylifera L.)" 59 : 531-535, 2005

      7 Edagawa Y., "Systemic administration of lentinan, a branched b-glucan, enhances longterm potentiation in the rat dentate gyrus in vivo" 314 : 139-142, 2001

      8 Xiao Fei Du, "Synergistic Immunostimulating Activity of Pidotimod and Red Ginseng Acidic Polysaccharide against Cyclophosphamide-induced Immunosuppression" 대한약학회 31 (31): 1153-1159, 2008

      9 Kim YS, "Study on antitumor and immunomodulating activities of polysaccharide fractions from Panax 276 NI ET AL. ginseng: comparison of effects of neutral and acidic polysaccharide fraction" 13 : 330-337, 1990

      10 Sonoda Y., "Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng" 38 : 287-294, 1998

      11 Ni W., "Preparation of a glucan from the roots of Rubus crataegifolius Bge. and its immunological activity" 344 : 2512-2518, 2009

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      15 Chen J., "Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor-bearing mice" 78 : 2742-2748, 2006

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      17 Nair PKR, "Mechanism of macrophage activation by (1,4)-a-dglucan isolated from Tinospora cordifolia" 6 : 1815-1824, 2006

      18 Liu C., "Macrophage activation by polysaccharide biological response modifier isolated from Aloe vera L. var. chinensis (haw.) berg" 6 : 1634-1641, 2006

      19 Iacomini M., "Isolation and partial characterization of a pectic polysaccharide from the fruit pulp of Spondias cytherea and its effect on peritoneal macrophage activation" 76 : 676-683, 2005

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      22 Zhou G., "In vivo antitumor and immunomodulation activities of different molecular weight lambda-carrageenans from Chondrus ocellatus" 50 : 47-53, 2004

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      25 Moradali MF, "Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi)" 7 : 701-724, 2007

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      27 Hyun-Sook Kim, "Effects of Elm Bark (Ulmus davidiana var. japonica) Extracts on the Modulation of Immunocompetence in Mice" 한국식품영양과학회 10 (10): 118-125, 2007

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      29 Stuelp-Campelo PM, "Effect of a soluble a-d-glucan from the lichenized fungus Ramalina celastri on macrophage activity" 2 : 691-698, 2002

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      33 Fu P., "Chemical properties and anti-tumor activity of polysaccharides from roots of Panax ginseng" 20 : 439-441, 1994

      34 Zheng R., "Characterization and immunomodulating activities of polysaccharide from Lentinus edodes" 5 : 811-820, 2005

      35 Schepetkin IA, "Botanical polysaccharides: macrophage immunomodulation and therapeutic potential" 6 : 317-333, 2006

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      37 Lee SJ, "Antimetastatic and immunomodulating properties of a new herbal prescription, bojung-bangam-tang" 3 : 147-157, 2003

      38 Yoon TJ, "Anti-tumor metastatic activity of b-glucan purified from mutated Saccharomyces cerevisiae" 8 : 36-42, 2008

      39 Li X., "Anti-tumor and immunomodulating activities of proteoglycans from mycelium of Phellinus nigricans and culture medium" 8 : 909-915, 2008

      40 Lee YS, "Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsan isolated from Panax ginseng" 17 : 323-331, 1997

      41 Kim GY, "Acidic polysaccharide isolated from Phellinus linteus induces nitric oxide-mediated tumoricidal activity of macrophages through protein tyrosine kinase and protein kinase C" 309 : 399-407, 2003

      42 Sedmark JJ, "A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250" 79 : 544-552, 1979

      43 Mi-Hyoun Park, "A Polysaccharide Extracted from Rice Bran Fermented with Lentinus edodes Enhances Natural Killer Cell Activity and Exhibits Anticancer Effects" 한국식품영양과학회 10 (10): 25-31, 2007

      44 Jung ID, "5-Fluorouracil inhibits nitric oxide production through the inactivation of IkB kinase in stomach cancer cells" 64 : 1439-1445, 2002

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2014-06-24 학회명변경 한글명 : 한국식품영양과학회지 -> 한국식품영양과학회
      영문명 : Journal of the Korean Society of Food Science and Nutrition -> The Korean Society of Food Science and Nutrition
      KCI등재
      2014-04-02 학회명변경 한글명 : 한국식품영양과학회 -> 한국식품영양과학회지
      영문명 : 미등록 -> Journal of the Korean Society of Food Science and Nutrition
      KCI등재
      2013-10-01 평가 SCOPUS 등재 (등재유지) KCI등재
      2010-01-01 평가 SCI 등재 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2006-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2005-01-20 학술지등록 한글명 : Journal of Medicinal Food
      외국어명 : Journal of Medicinal Food
      KCI등재후보
      2005-01-20 학술지등록 한글명 : Journal of Medicinal Food
      외국어명 : Journal of Medicinal Food
      KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.88 0.33 1.35
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.09 0.84 0.536 0.08
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