비탈분극성 근육이완의 길항시 Atropine, Neostigmine 과 Glycopyrrolate, Neostigmine 의 혼합 정주가 심박수에 미치는 영향 = The Effect of Atropine-Neostigmine and Glycopyrrolate-Neostigmine Mixture on Heart Rate

다국어 초록 (Multilingual Abstract)

Clinically, neostigmine is most commonly used as the reversal agent for to the competitive muscle relaxants. Atropine (group 1) and glycopyrrolate (group 2) were studied in doses of 15ug/kg, 20 ug/kg and 77ug/kg, 10ug/kg given intravenously in a mixture with neostigm-ine 40ug/kg, during operation and at the end of operation 20 ASA class I patients, aged between 15 to 60, were selected in each group.
Anesthesia was maintained with enflurane (1-1.5%), N_2O (2L/min), O_2(2L/min) and pancuronium (50ug/kg) was used as a muscle relaxant.
The results were as fellows :
1) Group 1 showed significant increase and decrease in pulse rate compared with group 2.
2) Atropine-neostigmine mixture significantly showed initial increase and late decrease in pulse rate than glycopyrrolate-neostigmine mixture.
3) In group 2, 20㎍/kg dose of atropine, when administered in a mixture with neostigmine, showed significant initial increase in pulse rate, 15㎍/kg dose of atropine showed significant late bradycardia.
4) In group 2, 7 ㎍/k, 10 ug/kg dose of glycopyrrolate was not associated with initial tachy cardia but late bradycardia was obserred and 10 ㎍/kg dose of glycopyrrolate was associated with more stable heart rate.