가시오가피 추출물이 마크로파지 활성과 우유의 발효 중 젖산균 성장에 미치는 영향 = Effects of Acanthopanax senticosus Extract on Macrophage Activity and the Growth of Lactic Starter Culture during Fermentation

다국어 초록 (Multilingual Abstract)

We examined the effect of Acanthopanax senticosus extract on macrophage activity and its effect on the growth of lactic starter culture when added to fermented milk. Greater amounts of Acanthopanax senticosus extract correlated with higher macrophage activity (p<0.05), in particular at $1,000\;{\mu}g/mL$. Water extract of Acanthopanax senticosus resulted in higher levels of nitric oxide (NO) than 70% ethanol extract at $1,000\;{\mu}g/mL$. In contrast, 70% ethanol extract resulted in higher $interleukin-1{\alpha}\;(IL-1{\alpha})$ and Tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$ levels than water extract. The growth of lactic starter culture was inhibited by increasing amounts of Acanthopanax senticosus water extract, resulting in a lower decrease in pH. A stirred type or drink type fermentation process seemed more suitable than a set type for the proper production of Acanthopanax senticosus extract added to fermented milk.

참고문헌 (Reference)

1 "축산물의 가공기준 및 성분규격" (2005-2) : 21-, 2005

2 신재용, "내마음대로 달여 마시는 건강약재" 삶과꿈 139-, 1997

3 A, "powerful inhibitors ofhistamine release induced by anti-immunoglobulin E fromrat peritoneal mast cells" ciwujia (ciwujia): 661-662, 1992

4 Gaffiney, B. T, "Panaxginseng and Eleutherococcus senticosus may exaggerate analready existing biphasic response to stress via inhibition ofenzymes which limit the binding of stress hormones to theirreceptors" 56 : 567-572, 2001

5 Park, S. Y, "New 3,4-seco-lupane-type triterpene glycosides from Acanthopanax senticosus forma inermis" 63 : 1630-1633, 2000

6 Bae, E. A, "Metabolism of chiisanoside fromAcanthopanax divaricatus var albeofructus by human intestinalbacteria and its relation to some biological activities" 24 : 582-585, 2001

7 Jeong, H. J, "Inhibitory effects of mast cell-mediated allergic reactionsby cell cultured Siberian ginseng" 23 : 107-117, 2001

8 Hibasami, H, "Induction of apoptosisby Acanthopanax senticosus HARMs and its component sesamin in human stomach cancer KATO III cells" 7 : 1213-1216, 2000

9 Davydov, M, "Eleutherococcus senticosus Maxim. (Araliaceae) as an adaptogen : a closerlook" 72 : 345-393, 2000

10 Yoon, T. J, "Effect ofhot water extract from Acanthopanax senticosus on systemicanaphylaxis" 34 : 518-523, 2002

11 Dowling, E. A, "Effect of Eleutherococcussenticosus on submaximal and maximal exerciseperformance" 28 : 482-489, 1996

12 Hacker, "Cytotoxic effects of E senticosusaqueous extract against L1210 leukemia cells" 270-272, 1984

13 Ha, E. S, "Competitive ELISA for the measurement of glycoprotein purified from Acanthopanax senticosus" 35 : 1209-1215, 2003

14 Lin, C. C, "Antioxidant and hepatoprotectiveeffects of Acanthopanax senticosus" 14 : 489-494, 2000

15 Yi, J. M, "Acanthopanax senticosus root inhibitsmast cell-dependent anaphylaxis" 312 : 163-168, 2001