한국여성에 있어서 산과력이 폐경 후 골밀도에 미치는 영향 = Relationship between Bone Mineral Density and Obstetric History in Korean Women

다국어 초록 (Multilingual Abstract)

The percentage of postmenopausal female population is in increase, and the importance of its medical and psychological implication has been highly appreciated. Menstrual irregularity, flushing and emotional problems can cause considerable distress during menopause. It is well known that hormone replacement therapy can relieve the menopausal symptoms, reduce risk of osteoporosis and coronary artery disease. In this point of view, author investigated the effect of HRT in postmenopausal women and to evaluate the relationship of parity and bone mineral density. The results were as follows: 1. The mean age of the studied patient was 54.3 years; treatment duration 4.9 years, gravity 5.9, parity 2.9 and mean number of living children were 2.8. 2. Naturally menopaused women were in 68.7%, while 1.7% were surgically menopaused and 29.6% were in perimenopause. 3. The symptoms complained by the patients were hot flush (25.8%), insomnia, urinary frequency (7.5%), back pain and arthralgia (7.5%) in its order and asymptomatic patient were in 24.1%. 4. The used HRT regimen in this study was livial (tibolon)(69.5%), combined premarin and provera (21.3%) and premarin only (1.7%). 5. After the HRT, the serum total cholesterol level decreased from 200 mg/dl to 197.2 mg/dl, triglyceride from 123.2 mg/dl to 94.2 mg/dl. Serum HDL cholesterol level increased form 47.9 mg/dl to 50.7 mg/dl. 6. After the HRT, the mean T-score increased from -1.42 to -1.07 and the mean Z-score, from -0.67 to -0.22. 7. There was tendency of decrease in bone mineral density with increase of gravity and parity. These results suggest that hormone replacement therapy can improve the symptoms of menopause and decrease the risk of osteoporosis and coronary artery disease in postmenopausal women considerably. Furthermore, we should liberally promote the use of the hormone replacement therapy and counsel women about the menopause and an individualized therapy and this will be possible by more studies on the quality of women's life.