타액과 혈중 Phenobarbital 농도의 비교연구 = Comparative Study on Plasma Total and Salivary Phenobarbital Concent

다국어 초록 (Multilingual Abstract)

Antiepileptic drug monitoring is essential to the rational medical therapy of the epilepsies. Present methods for monitoring plasma phenobarbital measure total drug levels, wherease only the non-protein-bound (free) fraction is considered to be biologically active. Since CSF fluid and saliva are both low-protein fluids, salivary phenobarbital levels correlate with plasma free and CSF levels. Measurement of phenobarbital in saliva provides a noninvasive method of obtaining repeated samples. Salivary phenobarbital concentration is dependent on the PH of the salive at the moment of sampling.
This study was performed to develop a correlation between plasma total and salivary phenobar bital levels by the High Performance liquid Chromatography in 39 Patients.
The following results were obtained;
1) Among 39 Patients males were 24(61.5%), and females were 15(38.5%), giving sex ratio 1.6:1, Majority(41%) of cases were between 6 and 10 years.
2) The mean salivary PH is 7.28±0.25.
3) The mean plasma total phenobarbital concentration was 13.77±5.00ug/ml and salivary concent. was 5.04±2.20 ug/ml. In correlation between plasma total phenobarbital concent. and salivary phenobarbital concent., liner regression equation is y=0.077+0.359×(y:salivary phenobarbital concent., x:plasma total phenobarbital concent) with correlation efficient(r)=0.73.
4) The mean salivary phenobarbital levels as a percent of plasma total levels were 34.7% at salivary PH values less than 7.0, 37.1% at PH values from 6.0 to 7.4, 37.5% PH values greater than 7.4 and 36.2% in overall cases.
5) In correlation between salivary phenobarbital concent./plasma total ptenobarbital concent (%) and salivary PH, linear regression equation is y=-1.52+5.24×(y:salivary phenobarbital concent./plasma total phenobarbital concent. x 100, x:salivary PH) with correlation efficient (r)=0.696.