제왕절개술후 정맥로를 이용한 자가통증조절 방법에서 Morphine과 Ketorolac의 비교 = Comparison of Morphine and Ketorolac in Intravenous Patient Controlled analgesia after Cesarean Section

다국어 초록 (Multilingual Abstract)

Morphine for the intravenous patient controlled analgesia (Ⅳ-PCA) provides effective postoporativo pain control, but has side effects such as itching, nausea and vomiting. Meanwhile, ketorolac is a non narcotic, non-steroidal analgesic that may provide postoperative analgesia without opioid related side effects, In this study, attempt was made to determine the relative efficacy and side effect of ketorolac administered by Ⅳ-PCA in comparison with morphine, for control of postoperative pain.
Fourty ASA physical status Ⅰ or Ⅱ female patients undergoing cesarean section were randomly allocated into one of two group according to type of drug used (n=20 for each group). The group were divided to group M (morphine 100 ㎎), group K (ketorolac 300 ㎎). Drugs for each group were mixed with 90 ㎖ saline(tota1 amount: 100 ㎖) for infusion. Loading dose. PCA dose and lockout interval was 0.05 ㎖/㎏, 0.02 ㎖/㎏ and 8 minute, respectively, In each group visual analog scale(VAS), pain score, sedation score, degree of satisfaction, history of attempt, injection and incidence of side effects were checked.
Mean VAS and pain score in morphine group were less than in ketorolac group at each time, but only significantly at 48 hour. The incidence of nausea in ketololac group was lower than that in morphine group. The degree of satisfaction was significantly high in morphine group.
It is thought that IV ketorolac PCA, although alleviates moderate to severe pain in postoperative period, has limited effectiveness as the sole postoperative analgesic.