Usefulness of Mitral Annulus Velocity for the Early Detection of Left Ventricular Dysfunction in a Rat Model of Diabetic Cardiomyopathy|RISS 상세보기

다국어 초록 (Multilingual Abstract)

Background: Diabetic cardiomyopathy (DMCMP) is characterized by myocardial dysfunction regardless of coronary artery disease in diabetic patients. The features of LV dysfunction in rat model of type 1 DM induced by streptozocin, are variable and controversial. Thus, we tested the usefulness of tissue Doppler imaging in the early detection of ventricular dysfunction in a rat model of DMCMP.
Methods: Diabetes was induced by intra-peritoneal injection of streptozocin (70 mg/kg) in 8 weeks of Sprague-Dawley rat.
Diagnosis of diabetes was defined as venous glucose level over 350 mg/dL 48 hrs after streptozocin injection.
Echocardiography was done at baseline and 10 weeks after diabetes induction both in diabetes group (n=15) and normal control (n=10). After echocardiography at 10 weeks, invasive hemodynamic measurement using miniaturized conductance catheter was done in both groups.
Results: Ten weeks after diabetes induction, heart and lung mass indexes of diabetes were larger than those of normal control (3.2±0.3 vs. 2.4±0.2 mg/g, p＜0.001, 5.5±1.1 vs. 3.6±0.6 mg/g, p＜0.001, respectively). In echocardiographic data, s’ (2.4±0.4 vs. 3.1±0.5 cm/s, p＜0.001), e’ velocity of mitral annulus (2.9±0.6 vs. 3.8±1.1 cm/s, p＜0.001), and E/e’ ratio (27.1±5.6 vs. 19.7±2.6, p＜0.001) were impaired in diabetes group. In hemodynamic measurement, there were no differences in ejection fraction, peak dP/dt between the diabetic group and normal control. However, load independent indexes of contractility, the slope of the end-systolic pressure volume relation (0.18±0.07 vs. 0.62±0.18 mmHg/μL, p ＜0.001) and preload recruitable stroke work (51.8±22.0 vs. 90.9±22.5 mmHg, p＜0.001) were impaired in diabetic group compared to normal control.
Conclusion: In a rat model of diabetic cardiomyopathy, tissue Doppler imaging of mitral annulus can be a good modality for early detection of myocardial dysfunction.

번역하기

참고문헌 (Reference)

1 김용진, "조직도플러영상" 한국심초음파학회 11 (11): 63-69, 2003

2 Sherif F. Nagueh, "Tissue Doppler Imaging for the Assessment of Left Ventricular Diastolic Function" 한국심초음파학회 16 (16): 76-79, 2008

3 Yoon YS, "Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor" 111 : 2073-2085, 2005

4 Tschöpe C, "Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene" 18 : 828-835, 2004

5 Boyer JK, "Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus" 93 : 870-875, 2004

6 Cai L, "Oxidative stress and diabetic cardiomyopathy: a brief review" 1 : 181-193, 2001

7 Rubler S, "New type of cardiomyopathy associated with diabetic glomerulosclerosis" 30 : 595-602, 1972

8 Fiordaliso F, "Myocyte death in streptozotocin-induced diabetes in rats in angiotensin II- dependent" 80 : 513-527, 2000

9 Tschöpe C, "Myocardial expression of rat bradykinin receptors and two tissue kallikrein genes in experimental diabetes" 44 : 35-42, 1999

10 Pacher P, "Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats" 3 : 1422-1434, 2008