태권도 호신술 트레이닝이 중년 여성의 뇌유래신경영양인자와 마이오카인 카텝신 B에 미치는 영향 = The Effect of Taekwondo Self-defense Training on Brain-Derived Neurotrophic Factor and Myokine Cathepsin B in Middle-aged Women

국문 초록 (Abstract)

목적 본 연구의 목적은 12주간의 태권도 호신술 트레이닝 프로그램이 중년 여성의 BDNF, IGF-1과 마이오카인 CTSB에 미치는 영향을 규명하는 것이다.
방법 중년 여성 20명을 대상으로 대조군(CG: 10명), 태권도 호신술 군(TSG: 10명)으로 무선 배정하였으며 태권도 호신술 트레이닝군은 1회 60분, 주 4회, 총 12주간 트레이닝 프로그램에 따라 운동을 실시하였다. 태권도 호신술 트레이닝 시작 전과 후에 각각 신체 조성, 기초체력검사와 혈액 채혈을 실시하였다.
결과 12주간 태권도 호신술 트레이닝에 따른 배근력, 팔굽혀펴기, 사이드스텝, 높이뛰기, 혈청 BDNF, IGF-1, CTSB에서 상호작용 효과가 나타났으며(P<.05), 이에 대한 주 효과 분석 결과 그룹 간 차이에서 사후 CG와 비교하여 TSG에서 유의하게 증가한 것으로 나타났다(P<.05). 또한 태권도 호신술 트레이닝에 따른 CTSB와 BDNF의 변화량은 유의한 정적 상관(r=0.881, P=0.001)이 나타났다.
결론 태권도 호신술 트레이닝은 BDNF, IGF-1와 마이오카인 CTSB를 증가시키는 데 효과적이었으며, 태권도 호신술 트레이닝 프로그램으로 인한 CTSB와 BDNF의 변화량은 유의한 상관관계가 나타나 CTSB의 증가에 따른 BDNF의 향상이 관계가 있음을 시사한다. 따라서 태권도 호신술 트레이닝은 노화의 진행 단계에 있는 중년 여성에서 기초체력을 증가시킬 뿐만 아니라 뇌기능과 관련된 마이오카인을 증가시킴으로써 신경영양인자의 발현을 향상시켜 인지 기능에 긍정적인 영향을 미치는 것으로 사료된다.

다국어 초록 (Multilingual Abstract)

Purpose The purpose of this study was to investigate the effects of 12-week taekwondo self-defense training program on BDNF, IGF-1 and myokine CTSB in middle-aged women.
Method 20 middle-aged women over the age of 45 were randomly assigned to the control group(CG, n=10) and the taekwondo self-defense group(TPG, n=10). Taekwondo self-defense group exercised according to training programs for 60 minutes once, 4 times a week, for a total of 12 weeks. Body composition, fitness test and blood collection were performed before and after 12 weeks of taekwondo training, respectively.
Results BDNF significantly increased after training in TSG compared to before training, and significantly increased in TSG compared to CG after training. IGF-1 significantly increased after training in TPG and TSG, and CTSB significantly increased after training in TSG only. In addition, there was a significant positive correlation between the delta values of serum CTSB and BDNF due to taekwondo training.
Conclusion Taekwondo self-defense training was effective in increasing BDNF, IGF-1 and myokine CTSB. The delta values of CTSB and BDNF from the Taekwondo self-defense training program showed a significant correlation, suggesting that the increase of CTSB is associated with the improvement of BDNF. Therefore, Taekwondo self-defense training is thought to have a positive effect on cognitive function by enhancing the expression of neurotrophin by increasing the myokine related to brain function as well as increasing physical fitness in middle-aged women in the advanced stage of aging.

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