단순 Methacholine 흡입법에 의한 비특이성 기도과민반응검사 = Simple Methacholine Inhalation Challenge Test : Presumptive Estimation of Provocation Concentration from the Percent Changes of Spirometric measurements단순 Methacholine 흡입법에 의한 비특이성 기도과민반응검사

다국어 초록 (Multilingual Abstract)

The usual methacholine challenge procedures are quite time consuming. So the presumptive estimation of the provocation concentration from the percent changes of spirometric measurements was performed in 22 asthmatics, 17 allergic rhinitis pathents and 40 normal subjects. In asthmatics inhalation of 2mg/ml methacholine resulted in a 19.3% diminution in FEV1 and PC20 was estimated approximately as 2 mg/ml. But in allergic rhinitis patients and normal subjects PC20, were higher than 20 mg/ml because their responses to 20 mg/ml methacholine were -5.9% and -1.8%, respectively. The baseline lung function of responders (asthmatics in whom FEV, decreased by more than 15%) was lower than nonresponders (p<0.001), and a significant correlation was present between the baseline FEV, and % change FEV1 (r=0.46, p<0,05). These results suggested that PC20 is different according to the severity of the bronchial obstruction and it indicate the bronchial hyperreactivity of the present time. This simple, rapid method using the solutions of 2 mg/ ml and 20 mg/ml methacholine may give a rough but clinically useful information about the bronchial hyper- reactivity like as reactive to 2mg/ml, intermediate response, or nonreactive even to 20 mg/ml.