Biodegradable Polyaspartamide-g-C18/DOPA/GLY-NEO Nano Aggregates for Wound Closure/Healing with Antifungal Activity

다국어 초록 (Multilingual Abstract)

In this study, this biocompatible and biodegradable PSI-based nano-aggregates were developed as a wound closing/healing adhesives. In addition to its adhesive effect without toxicity, antifungal drug was loaded for faster wound healing. The hydrophobic C18 and DOPA were grafted onto the PSI to form adhesive nano-aggregates. Neomycin (NEO), an antifungal drug, is conjugated with glycine to enable pH-dependent drug release. While the chemical and physical structure of the synthesized polymers and nano aggreages were analyzed, the drug release patterns as well as wound adhesional properties of nano aggregates were in vitro and in vivo investigated. As a nano-adhesive that simultaneously release antifungal drugs, this material is expected to have a significant impact on wound healing efficiency.