桃仁承氣湯과 柱枝茯笭丸이 瘀血病態에 미치는 藥力比較硏究 = Comparative Study on the Effects of Doinseunggitang and Kyejibokryonghwan in Blood Stasis Model

다국어 초록 (Multilingual Abstract)

In order to compare the effects of Doinseunggitang and Kyejibokryonghwan on both 'dextran-induced blood stasis model(Dx Model)' and 'hydrocortisone acetate(HA)-induced blood stasis model(HA Model)', rats of Dx Model treated with 10% dextranaqueous solution (i.v.injection, 1.1㎖/200g/day through caudal vein, once) were orally administrated liquid extract of Doinseunggitang and Kyejibokryonghwan, and then observed platelet, fibrinogen, prothrombin time, hematocrit and FDP level.
Another rats of HA Model (i.m.injection, 5mg/200g/day into the muscular rump, for 7 days) were orally administrated liquid extract of Doinseunggitang and Kyejibokryonghwan, thereafter measured platelet, fibrinogen, prothrombin time and hematocrit.
The results were summarized as follows:
1.Platelet was stitistically significantly increased in Doinseunggitang group than Kyejibokryonghwan Group on both Dx Model and HA Model.
2.Fibrinogen Level was increased in Doinseunggitang group than Kyejibokryonghwan Group on both Dx Model and HA Model.
3.Prothrombin time was shortened in Doinseunggitang group than Kyejibokryonghwan Group on both Dx Model and HA Model.
4.Hematocrit was stitistically significantly increased in Doinseunggitang group compared with data of control group on Dx Model, but was decreased on HA Model.
5.FDP was more decreased in Doinseunggitang group than Kyejibokryonghwan Group on Dx Model.