기저세포암과 편평세포암에서 세포각질의 발현에 관한 연구 = Cytokeratin Kxpression in Basal Cell Carcinoma and Squsmous Cell Carcinoma기저세포암과 편평세포암에서 세포각질의 발현에 관한 연구

다국어 초록 (Multilingual Abstract)

Background : The histologic distinction between basal cell carcinoma(BCC) and squamous cell carcinoma(SCC) is sometimes difficult, but clinically important, because SCC has worse prognosis than BCC. Cytokeratins(CKs) are the major component of intermediate filaments and are subdivided into at least ２０ different polypeptides. Monoclonal antibodies developed against these individual keratins become very useful in the classification of the major types of epithelial tumors. Objective : The purpose was to investigate the usefulness of CK staining in distinguishing BCC from SCC. Methods : We studied １０ cases of BCC and １０ cases of SCC with ６ anticytokeratin antibodies including AEI, CAM５.２, CK７, CKl６, CK１０, and CK８. Results : All cases of BCC and SCC stained with AEI. Six and ５ cases out of １０ cases of BCC stained with CAM５,２ and CK７, respectively, but all cases of SCC stained with neither CAM５.２ nor CK７. All cases of SCC stained with CKl６, but all cases of BCC did not. Two out of １０ cases of SCC stained focally with CK１０, while all cases of BCC did not stain with CK１０. All cases of BCC and SCC did not stain with CK８. Conclusion : We conclude that a panel of antibodies for CKs including CK７, CAM５.２, and CKl６ may be useful in distinguishing BCC from SCC. In particular, CKl６ may be the most useful marker because it was positive for all cases of SCC while negative for all cages of BCC. (Korean J Dermatol ２００２;４０(１２) : １４８１∼１４８６)