RISS 검색 - 국내학술지논문 상세보기

다국어 초록 (Multilingual Abstract)

Background/Aims: Nonalcoholic fatty liver disease (NAFLD) may be one of the important causes of cryptogenic hepatocellular carcinoma (HCC). The aim of this study was to evaluate whether patients with cryptogenic HCC share clinical features similar to that of NAFLD. Methods: Cryptogenic HCC was defined as HCC that occurs in patients with the following conditions: HBsAg(-), anti-HCV(-), and alcohol ingestion of less than 20 g/day. All patients diagnosed with cryptogenic HCC from 2005 to 2012 (cryptogenic HCC group), and all patients diagnosed with HBV associated HCC between 2008 and 2012 (HBV-HCC group) were enrolled in the present study. Clinical features, BMI, lipid profiles, presence of diabetes mellitus, hypertension, and metabolic syndrome were compared between the two groups. Results: Cryptogenic HCC group was composed of 35 patients (19 males and 16 females) with a mean age of 70±11 years. HBV-HCC group was composed of 406 patients (318 males and 88 females) with a mean age of 56±7 years. Patients in the cryptogenic HCC group were older (p=0.001) and female dominant (p=0.042) than those in the HBV-HCC group. There were no differences in the laboratory test results including lipid profiles and Child-Turcotte-Pugh class between the two groups. Patients in the cryptogenic HCC group had higher prevalence of diabetes (37% vs. 17%, p=0.015), hypertension (49% vs. 27%, p=0.051), metabolic syndrome (37% vs. 16%, p=0.001), and higher BMI (25.3 kg/m2 vs. 24.1 kg/m2, p=0.042) than those in the HBV- HCC group. The tumor stage was more advanced (stage III and IV) at diagnosis in the cryptogenic HCC group than in the HBV-HCC group (60% vs. 37%, p=0.007). Conclusions: Cryptogenic HCC has clinical features similar to that of NAFLD and is diagnosed at a more advanced tumor stage.

참고문헌 (Reference)

1 오길찬, "한국인에서 원인미상 간세포암은 증가하는가?" 대한소화기학회 45 (45): 45-51, 2005

2 James WP, "WHO recognition of the global obesity epidemic" 32 (32): S120-S126, 2008

3 Ohki T, "Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH" 58 : 839-844, 2009

4 Choi SY, "The relation between non-alcoholic fatty liver disease and the risk of coronary heart disease in Koreans" 104 : 1953-1960, 2009

5 Bhala N, "The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study" 54 : 1208-1216, 2011

6 Ascha MS, "The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis" 51 : 1972-1978, 2010

7 Edge SB, "The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM" 17 : 1471-1474, 2010

8 Baranova A, "Systematic review: association of polycystic ovary syndrome with metabolic syndrome and non-alcoholic fatty liver disease" 33 : 801-814, 2011

9 Suk KT, "Revision and update on clinical practice guideline for liver cirrhosis" 18 : 1-21, 2012

10 Hashizume H, "Primary liver cancers with nonalcoholic steatohepatitis" 19 : 827-834, 2007