High Prevalence of Thyroid Disease and Role of Salivary Gland Scintigraphy in Patients with Xerostomia

다국어 초록 (Multilingual Abstract)

Purpose Although Sjögren’s syndrome (SS) is the most commondisease causing xerostomia, autoimmune thyroid diseasescan also affect the salivary glands. The aim of our studywas to estimate the prevalence of thyroid diseases (TD) insubjects with symptoms of xerostomia and evaluate the efficacyof salivary gland scintigraphy (SGS) in the detection ofTD in patients with SS and without SS.
Methods We retrospectively reviewed the SGS findings of173 subjects (men:women, 29:144) with symptoms ofxerostomia. Ejection fractions (EF) in the parotid and submandibularglands were calculated. Thyroid disease was diagnosedon the basis of the results of the visual assessment oftracer uptake in the thyroid gland on SGS images as well asserological thyroid function tests.
Results Based on theAmerican-European Criteria, 94 patientswere diagnosed with SS. Hashimoto’s thyroiditis was diagnosedin 63 patients, subacute thyroiditis in 23, subclinicalhypothyroidism in five, and Graves’ disease in one. Therewere significant differences in the EF values of the parotidand submandibular glands between patients with TD andthose with undetermined diagnoses.
Conclusions More than half of patients with xerostomia exhibitedTD. Thyroid assessment by SGS is feasible, and SGSappears to be useful for the patients with xerostomia caused byTD. SGS may be the first imaging modality capable of evaluatingboth salivary gland function and thyroid gland status inpatients with xerostomia. This strategy would make the requirementfor additional workup for thyroid disease.

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