The author observed morphological change in palate development of rat embryo
after irradiation of x-ray on the one side of the duplex uterus.
The time-matings occured between 6 p.m. and 8 a.m. and all females with copulation plugs at 8 a.m. were is...
The author observed morphological change in palate development of rat embryo
after irradiation of x-ray on the one side of the duplex uterus.
The time-matings occured between 6 p.m. and 8 a.m. and all females with copulation plugs at 8 a.m. were isolated and properly marked for evidence of copulation. The lower left abdomen of mothers were exposed to x-radiation on the 7 1/2th, 9 1/2th, 11 1/2th day of gestation, respectively 150, 250, 350, 500rads.
At 18 1/2th day of post-conception, the pregnant females were dissected and the contents of the two uteri examined.
The translucent sample by Alizarin red S stain were prepared.
The results were as follows;
1. The result that groups irradiated by 250rads and 350rads made marked difference in comparison with the control group suggests the x-ray to be a inducing factor of cleft palate.
2. At 11 1/2th day of gestation, incidence of cleft palate induced by x-irradiation was highest.
3. Mortality showed the highest frequency at 7 1/2th day of gestation and tended to decrease in according to increasing of age.
4. Morphology of cleft palate induced by x-irradiation showed similarity in comparison with those induced by other factors having reported ever.