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      Rat에서의 Propranolol 염산염의 비강흡수에 관한 연구 = Studies on the Nasa Absorption of Propranolol Hydrochloride in Rat

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      https://www.riss.kr/link?id=A19634273

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      Nasal absorption of Propranolol was evaluated in rat by perfusing method of
      Propranolol solution. And the effect of additives (Epinephrine, Sodium
      lauryl sulfate, Span 20 and Tween 80) were estimated for Nasal absorption
      by perfusion method. Each solution was circulated through the nasal cavity
      of rat by means of a peristaltic pump at the rate of 2.0ml/min. and kept at
      37.5˚C. The absorption rate was determined from perfusing solution by
      Ultraviolet spectrophotometer at 288 nm versus time.
      As a result is follows
      1 . Nasal absorption rate coustant of Propranolol (Kα) is 1.78 × 10^-3 μ
      g/ ml/min.
      2 . Kα of solution contained Epinephrine is 1.13 × 10^-3 μg/ml/min.
      3 . Kα of solution contained Sodium lauryl sulfate is 6.10 × 10^-3 μ
      g/ml/min.
      4 . Kα of solution contained Span 20 is 3.07 × 10^-3 μg/ml/min.
      5 . Kα of solution contained Tween 80 ,s 2.45 × 10^-3 μg/ml/min.
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      Nasal absorption of Propranolol was evaluated in rat by perfusing method of Propranolol solution. And the effect of additives (Epinephrine, Sodium lauryl sulfate, Span 20 and Tween 80) were estimated for Nasal absorption by perfusion method. ...

      Nasal absorption of Propranolol was evaluated in rat by perfusing method of
      Propranolol solution. And the effect of additives (Epinephrine, Sodium
      lauryl sulfate, Span 20 and Tween 80) were estimated for Nasal absorption
      by perfusion method. Each solution was circulated through the nasal cavity
      of rat by means of a peristaltic pump at the rate of 2.0ml/min. and kept at
      37.5˚C. The absorption rate was determined from perfusing solution by
      Ultraviolet spectrophotometer at 288 nm versus time.
      As a result is follows
      1 . Nasal absorption rate coustant of Propranolol (Kα) is 1.78 × 10^-3 μ
      g/ ml/min.
      2 . Kα of solution contained Epinephrine is 1.13 × 10^-3 μg/ml/min.
      3 . Kα of solution contained Sodium lauryl sulfate is 6.10 × 10^-3 μ
      g/ml/min.
      4 . Kα of solution contained Span 20 is 3.07 × 10^-3 μg/ml/min.
      5 . Kα of solution contained Tween 80 ,s 2.45 × 10^-3 μg/ml/min.

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