Nasal absorption of Propranolol was evaluated in rat by perfusing method of Propranolol solution. And the effect of additives (Epinephrine, Sodium lauryl sulfate, Span 20 and Tween 80) were estimated for Nasal absorption by perfusion method. ...
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https://www.riss.kr/link?id=A19634273
1987
Korean
518.05
학술저널
15-36(22쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Nasal absorption of Propranolol was evaluated in rat by perfusing method of Propranolol solution. And the effect of additives (Epinephrine, Sodium lauryl sulfate, Span 20 and Tween 80) were estimated for Nasal absorption by perfusion method. ...
Nasal absorption of Propranolol was evaluated in rat by perfusing method of
Propranolol solution. And the effect of additives (Epinephrine, Sodium
lauryl sulfate, Span 20 and Tween 80) were estimated for Nasal absorption
by perfusion method. Each solution was circulated through the nasal cavity
of rat by means of a peristaltic pump at the rate of 2.0ml/min. and kept at
37.5˚C. The absorption rate was determined from perfusing solution by
Ultraviolet spectrophotometer at 288 nm versus time.
As a result is follows
1 . Nasal absorption rate coustant of Propranolol (Kα) is 1.78 × 10^-3 μ
g/ ml/min.
2 . Kα of solution contained Epinephrine is 1.13 × 10^-3 μg/ml/min.
3 . Kα of solution contained Sodium lauryl sulfate is 6.10 × 10^-3 μ
g/ml/min.
4 . Kα of solution contained Span 20 is 3.07 × 10^-3 μg/ml/min.
5 . Kα of solution contained Tween 80 ,s 2.45 × 10^-3 μg/ml/min.
Reactivity and Structure of Copper(Ⅱ) Complexes concerned with some Redox Recations
어린이와 Scopolamine Patch(KIMITE)
壓縮條件下에서 탄산수소나트룸과 상호작용에 미치는 Avicel의 영향에 관한 연구