ROS-responsive thioether-based nanocarriers for efficient pro-oxidant cancer therapy

다국어 초록 (Multilingual Abstract)

A high level of intracellular reactive oxygen species (ROS) is one of the remarkable intrinsic features ofcancer cells. Therefore, ROS-responsive drug carriers have received great attention for cancer-selectivedrug delivery. In this study, ROS-responsive thioether-bearing polymers (TEP) were synthesized foreffective intracellular delivery of piperlongumine (PL) into cancer cells. PL is a pro-oxidant drug thatinduces cytotoxic oxidative stress in cancer cells. PL-loaded TEP nanoparticles (PL-TEP NPs) weresuccessfully formulated by a nanoemulsion method. PL-TEP NPs showed ROS-sensitive disassembly,which leads to ROS-sensitive drug release. In addition, PL-TEP NPs showed higher cytotoxicity in humanbreast cancer cells (MCF-7) than in normal human dermalfibroblast cells (hDFB), demonstrating theircancer cell-specific pro-oxidant therapy. This study demonstrates that ROS-responsive TEP NPs areeffective drug carriers for efficient intracellular delivery of hydrophobic drug, PL.

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