韓國産 植物 Sorbus commixta HEDL이 사람 淋巴球에 미치는 細胞毒性 反應에 관한 硏究 = A Study on Lymphocyte Cytotoxicity by Sorbus commixta HEDL Extract

다국어 초록 (Multilingual Abstract)

The immune response is a complex process involving interactions among several different immunocompetent cells and their products. Receptors or allcantigens on the surface of these cells mediate some of the interactions and considerable investigation has been focused on components of the lymphocyte surface membrane. The precise dissection of the cellular mechanisms and interactions involved in the generation of the human immune response has been facilitated by recent advances in three interrelated areas; the development of in vitro methods for the characterization and identification of human lymphocyte classes by cell surface marker, the development of new techniques for isolation of highly purified subclasses of human lymphocytes and monocytes, and the development of in vitro techniques to discriminate the functional properties and interaction of the isolated subsets of lymphocytes.
More than 30 loci determining alloantigen of the cell surface by use these in vitro methods have been reported in mice, and the number is steadily increasing. The loci now known are conviniently divided into three groups: histocompatibility loci, blood group loci, and loci demonstrable by cytotoxicity of lymphocytes or lymphocyte-derived cells
The purpose of the present paper is to describe whether Sorbus commixta HEDI, extract can be used as a reagent detecting and alloantigen on lymphoid cells, or not.
By use of Sorbus commixta HEDL extract, lymphocyte cytotoxicity test: was performed with samples from 70 normal persons and 129 patients, and obtained following results:
1. On the basis of the results, human lymphocytes can be classified into two groups, one in cytotoxicity-positive group (11.0%) by Sorbus commixta HEDL extract, and the other is cytotoxicity-negative group (89.0%)
2. Sorbus commixta HEDL extract could be used as a reagent to detect some alloantigens on lymphocyte surface membrane.
3. To clarify the relationship between cytotoxycity test by Sorbus commixta HEDL, extract and certain diseases is required further studies.

목차 (Table of Contents)

• Ⅰ. 緖論
• Ⅱ. 材料 및 方法
• Ⅲ. 成績
• Ⅳ. 總括 및 考按
• Ⅴ. 結論
• 參考文獻