융모성 질환의 화학요법에 있어서 Citrovorum Factor Rescue의 효과에 관한 임상적 효과 = Clinical Study on Chemotherapy with Citrovorum Factor Rescure in Gestational Trophoblastic Disease

다국어 초록 (Multilingual Abstract)

Thirty patients with nonmetastatic gestational trophoblastic neoplasms (GTN) were treated primarily with methotrexate (MTX) alone in 15 out of 30 cases, and Methotrexate with citrovorum factor rescure (C.F) in 15 out of 30 cases. The comparative systemic toxicity of MTX-CF and MTX alone in the treatment of GTN was evaluated in this study . treatment with MTX-CF was associated with only a 6.7% incidence (1 out of 15 patients) of hepatic and/or hematologic toxicity, 6.7% incidence (1 out of 15 patients) of marked stomatitis and total absence of either a generalized rash or marked alopecia, In contrast MTX alone was associated with a 46.7% incidence (7out of 15 patients) of hepatic and/or hematologic toxicity and 40 % incidence ( 6 out 15 patients) of marked stomatitis. It was found that MTX-CF is less toxic single agent chemotherapeutic regimen than MTX alone in the management of GTN.