Melatonin이 주간 수면과 체온에 미치는 영향 = The Effects of Melatonin on Daytime Sleep and Body Temperature

다국어 초록 (Multilingual Abstract)

Author tried to evaluate the hypnotic effect of melatonin and melatonin induced daytime sleepiness and feeling of fatigue, and to identify the cumulative effect of short-term administration of melatonin for 3 successive days, and remaining effect after discontinuation. 6mg of melatonin was administered to healthy young males at 0900 hour, and the concurrent effects on sleep latency, daytime sleepiness and fatigue, and body temperature were recorded. Body temperature was recored every 15 minutes from 0900 to 2200 hours, and sleep latency was recorded using 2 hour multiple sleep latency test(MSLT). Daytime sleepiness and fatigue were checked using visual analogue test.
The result were summarized as follows.
1. The hypnotic effect of melatonin appeared within 1 hour, and the effect continued over 6 hours. Cumulative effect did not appear during 3 days of administration, and sleep latency was normal range on the day of discontinuation.
2. Melatonin induced daytime sleepiness and fatigue appeared within 1 hour after administration, and the condition continued over 6 hours. Cumulative effect did not appear during 3 days of administration, and on the day of discontinuation feeling of sleepiness and fatigue did not significant difference compare to baseline.
3. The longer the baseline sleep latency, the less feeling of sleepiness and fatigue, and feeling of daytime sleepiness and fatigue accompanied together regardless of mclatonin administration.
4. There was no significant correlation between sleep latency and body temperature during and after melatonin administration.