소화기 ; Desmopressin 복용 환자에서 발생한 중증 저나트륨혈증에 의한 동기능부전 증후군 1예 = Sick Sinus Syndrome Following Severe Hyponatremia Associated with Desmopressin Therapy

국문 초록 (Abstract)

DDAVP는 항이뇨 호르몬 유사체로 야뇨증 치료에 사용되고 있다. 그러나 주로 고령의 환자에게 DDAVP 투여 시 저나 트륨혈증이 생긴 예가 다양하게 보고되고 있다. 본 증례에서는 고령의 심부전 환자에서 장기간 DDAVP 투여로 중증 저나트륨혈증과 그로 인한 동기능부전이 발생하였으나 DDAVP를 중단하고 생리 식염수 정주 치료 등의 저나트륨혈증 교정 후에 증상 및 동기능이 모두 호전된 예를 경험하였기에이를 문헌고찰과 함께 보고하는 바이다.

다국어 초록 (Multilingual Abstract)

Desmopressin diacetate arginine vasopressin (DDAVP) is a synthetic analogue of the arginine vasopressin that is widely used in the treatment of diabetes insipidus, nocturnal enuresis, and polyuria. Although it is generally well-tolerated, DDAVP can cause hyponatremia, especially in elderly patients. There are many reports of DDAVP-induced hyponatremia, but there has been only one case report in which sinus node dysfunction was caused by severe hyponatremia. Here we report a case of sick sinus syndrome that occurred during an episode of severe hyponatremia induced by chronic use of desmopressin in a 91-year-old man who had nocturnal enuresis. (Korean J Med 2015,89:558-562)

참고문헌 (Reference)

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