원문 : 유산소 운동이 건강한 성인의 인슐린감수성과 말초혈액 단핵세포의 아디포넥틴 수용체 mRNA 발현에 미치는 영향 = Original Aryicle : Effects of Aerobic Exercise Training on Whole Body Insulin Sensitivity and PBMC Gene Expression of Adiponectin Receptors in Healthy Adults

다국어 초록 (Multilingual Abstract)

The purpose of this study was to investigate the effects of exercise training on whole body insulin sensitivity, serum adiponectin, and mRNAs of peripheral blood mononuclear cell(PBMC) adiponectin receptors in healthy young adults. Twelve young men were studied. We divided the subject into two groups: exercise group(N=6) and control group(N=6) as well as exercise group underwent 8 weeks of aerobic exercise. Primary outcomes of the study included body composition parameters including height, weight, body mass index, percent body fat, and waist circumference, hip waist circumference and waist-to-hip ratio and blood pressure and blood variable including resting blood pressures, total cholesterol, high-density lipoprotein cholesterol, triglycerides, fasting glucose, insulin and homeostasis assessment model of insulin resistance(HOMA-IR) and adipocytokine including serum adiponectin, HMW adiponectin, TNF-., IL-6. Analyses of variance with repeated measures were used to test any significant time×group interaction effects on the measured variables. Statistical significances were tested at p=0.05 with SPSS-PC(version 18.0). As a result, aerobic exercise group had significantly higher values in WC(p=.028), VO2max(p=.001), HMW adiponectin(p=.020) and TNF-.(p=.035), IL-6(p=.042), AUC for insulin(p=.018). The findings of the study suggest that 8 weeks of aerobic exercise training improved circulating adiponectin as well as inflammatory factors without any changes in PBMC adiponectin receptors mRNAs in adults.