주사 환자 278예에 대한 임상적 병리조직학적 고찰 = Rosacea: A Clinicopathological Study of 278 Patients in Korea주사 환자 278예에 대한 임상적 병리조직학적 고찰

다국어 초록 (Multilingual Abstract)

Background: Rosacea is characterized by erythema of the central face that persists for several months or longer. Reports of the histological changes in rosacea are scarce, and few attempts have been made to correlate suchchanges with clinical findings and pathophysiology. Objective: This study aimed to elucidate the clinical manifestations of rosacea and investigate its histologicalfeatures. Methods: We performed a retrospective analysis of 278 patients with histologically confirmed rosacea who visitedthe Department of Dermatology at the Catholic Medical Center between January 2008 and May 2013. Clinicalsubtypes, disease severity, and precipitating factors were evaluated. In 115 randomly selected patients, histopathologicalfeatures were evaluated as well. Results: The ratio of males to females was 1：1.8. The age distribution showed a peak incidence in the fifthdecade. The most common subtype was papulopustular rosacea (52.9%) followed by erythematotelangiectatic rosacea(34.9%), ocular rosacea (4.0%), and phymatous rosacea (2.9%). Granulomatous rosacea accounted for 5.4% ofrosacea cases. Precipitating factors included hot weather (54.7%), stress (51.8%), sun exposure (37.4%), alcohol(37.4%), and hot baths (33.1%). Histological analysis of skin biopsies from 115 patients revealed solar elastosis in62 patients (53.9%) and telangiectasia in 85 patients (73.9%).Conclusion: In this study, Korean rosacea patients were predominantly female with a peak age in the fifth decadeand the majority suffered from the papulopustular and erythematotelangiectatic types of rosacea. Histologicalobservations pertaining to each rosacea type were also discussed. (Korean J Dermatol 2015;53(1):1∼9)