갑상선유두암의 중심경부 림프절절제술 = Central Neck Dissection for Papillary Thyroid Carcinoma

다국어 초록 (Multilingual Abstract)

Considering the relatively good prognosis of papillary thyroid carcinoma, surgical treatment should be conducted with an adequate method and extent of surgery with minimal complications. The optimal indications and extent of central neck dissection in papillary thyroid carcinoma has been introduced by variable guidelines. However, there have been controversies in several aspects regarding central neck dissection (i.e., prophylactic versus therapeutic, unilateral versus bilateral), which will remain until a large prospective study is completed. Successful management of cervical lymph node metastasis in papillary thyroid carcinoma requires thorough preoperative evaluation, knowledge on adequate indications and extent of surgery and considerations on surgical anatomy. In this article, we reviewed the rationales for optimal central neck dissection in papillary thyroid carcinoma based on recent studies and presented the surgical strategy and skills based on personal experience of a single surgeon.

참고문헌 (Reference)

1 Stulak JM, "Value of preoperative ultrasonography in the surgical management of initial and reoperative papillary thyroid cancer" 141 (141): 489-494, 2006

2 Clark OH, "Thyroid cancer and lymph node metastases" 103 (103): 615-618, 2011

3 Zaydfudim V, "The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma" 144 (144): 1070-1077, 2008

4 Chisholm EJ, "Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone" 119 (119): 1135-1139, 2009

5 Harwood J, "Significance of lymph node metastasis in differentiated thyroid cancer" 136 (136): 107-112, 1978

6 Grodski S, "Routine level VI lymph node dissection for papillary thyroid cancer: surgical technique" 77 (77): 203-208, 2007

7 Sywak M, "Routine ipsilateral level VI lymphadenectomy reduces postoperative thyroglobulin levels in papillary thyroid cancer" 140 (140): 1000-1005, 2006

8 Shan CX, "Routine central neck dissection in differentiated thyroid carcinoma:a systematic review and meta-analysis" 122 (122): 797-804, 2012

9 American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, "Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer" 19 (19): 1167-1214, 2009

10 Zetoune T, "Prophylactic central neck dissection and local recurrence in papillary thyroid cancer: a meta-analysis" 17 (17): 3287-3293, 2010

11 Steinmuller T, "Prognostic factors in patients with differentiated thyroid carcinoma" 166 (166): 29-33, 2000

12 Ito Y, "Preoperative ultrasonographic examination for lymph node metastasis: usefulness when designing lymph node dissection for papillary microcarcinoma of the thyroid" 28 (28): 498-501, 2004

13 Koo BS, "Predictive factors for ipsilateral or contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma" 249 (249): 840-844, 2009

14 Machens A, "Pattern of nodal metastasis for primary and reoperative thyroid cancer" 26 (26): 22-28, 2002

15 Hay ID, "Papillary thyroid microcarcinoma: a study of 535 cases observed in a 50-year period" 112 (112): 1139-1146, 1992

16 Noguchi S, "Papillary thyroid carcinoma: modified radical neck dissection improves prognosis" 133 (133): 276-280, 1998

17 Kim MK, "Morbidity following central compartment reoperation for recurrent or persistent thyroid cancer" 130 (130): 1214-1216, 2004

18 Gemsenjager E, "Lymph node surgery in papillary thyroid carcinoma" 197 (197): 182-190, 2003

19 Low TH, "Lymph node status influences follow-up thyroglobulin levels in papillary thyroid cancer" 15 (15): 2827-2832, 2008

20 Wada N, "Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection" 237 (237): 399-407, 2003

21 Sippel RS, "Localization of recurrent thyroid cancer using intraoperative ultrasound-guided dye injection" 33 (33): 434-439, 2009

22 Ito Y, "Lateral and mediastinal lymph node dissection in differentiated thyroid carcinoma: indications, benefits, and risks" 31 (31): 905-915, 2007

23 Orloff LA, "Kuppersmith RB. American Thyroid Association's central neck dissection terminology and classification for thyroid cancer consensus statement" 142 (142): 4-5, 2010

24 Roh JL, "Is central neck dissection necessary for the treatment of lateral cervical nodal recurrence of papillary thyroid carcinoma?" 29 (29): 901-906, 2007

25 Moo TA, "Ipsilateral versus bilateral central neck lymph node dissection in papillary thyroid carcinoma" 250 (250): 403-408, 2009

26 Hughes DT, "Influence of prophylactic central lymph node dissection on postoperative thyroglobulin levels and radioiodine treatment in papillary thyroid cancer" 148 (148): 1100-1106, 2010

27 Tisell LE, "Improved survival of patients with papillary thyroid cancer after surgical microdissection" 20 (20): 854-859, 1996

28 Moo TA, "Impact of prophylactic central neck lymph node dissection on early recurrence in papillary thyroid carcinoma" 34 (34): 1187-1191, 2010

29 Triponez F, "Hook needle-guided excision of recurrent differentiated thyroid cancer in previously operated neck compartments: a safe technique for small, nonpalpable recurrent disease" 91 (91): 4943-4947, 2006

30 Cisco RM, "Extent of surgery for papillary thyroid cancer: preoperative imaging and role of prophylactic and therapeutic neck dissection" 13 (13): 1-10, 2012

31 Ahn JE, "Diagnostic accuracy of CT and ultrasonography for evaluating metastatic cervical lymph nodes in patients with thyroid cancer" 32 (32): 1552-1558, 2008

32 Guerrero MA, "Controversies in the management of papillary thyroid cancer revisited" 2011 : 303128-, 2011

33 Lundgren CI, "Clinically significant prognostic factors for differentiated thyroid carcinoma:a population-based, nested case-control study" 106 (106): 524-531, 2006

34 Ito Y, "Clinical significance of metastasis to the central compartment from papillary microcarcinoma of the thyroid" 30 (30): 91-99, 2006

35 Shah MD, "Clinical course of thyroid carcinoma after neck dissection" 113 (113): 2102-2107, 2003

36 Roh JL, "Chyle leakage in patients undergoing thyroidectomy plus central neck dissection for differentiated papillary thyroid carcinoma" 15 (15): 2576-2580, 2008

37 Shen WT, "Central neck lymph node dissection for papillary thyroid cancer:the reliability of surgeon judgment in predicting which patients will benefit" 148 (148): 398-403, 2010

38 Shen WT, "Central neck lymph node dissection for papillary thyroid cancer: comparison of complication and recurrence rates in 295initial dissections and reoperations" 145 (145): 272-275, 2010

39 Hughes DT, "Central neck dissection for papillary thyroid cancer" 18 (18): 83-88, 2011

40 Hartl DM, "Central compartment neck dissection for thyroid cancer: a surgical technique" 35 (35): 1553-1559, 2011

41 Forest VI, "Central compartment dissection in thyroid papillary carcinoma" 253 (253): 123-130, 2011

42 Stack BC Jr, "American Thyroid Association consensus review and statement regarding the anatomy, terminology, and rationale for lateral neck dissection in differentiated thyroid cancer" 22 (22): 501-508, 2012