알레르기비염에서 Pranlukast와 Cetirizine 병합요법의 치료효과 = Efficacy of a Combination with Pranlukast and Cetirizine in the Treatment of Allergic Rhinitis

다국어 초록 (Multilingual Abstract)

Background and Objectives：It has been suggested that the combination of a leukotriene receptor antagonist with an antihista-mine may have beneficial efects in the treatment of allergic rhinitis. The aim of this study were to evaluate the efects of combining a leukotriene receptor antagonist, pranlukast, and an antihistamine, cetirizine, to treat nasal symptoms of allergic rhinitis and the quality of life of the patients. Subjects and Method：Thirty-thre patients with allergic rhinitis were enrolled in this study. The control group (n= 12) received 5 mg cetirizine plus 120 mg pseudoephedrine twice a day while the study group (n= 21) received 5 ea, sneezing, nasal itching during the 7-day treatment period. They also answered the quality of life questionaire before and after the completion of 7-day treatment. Results：There were significant improvements in the nasal symptoms after the treatment in the control and the study group. However, there was no significant diference between the control and the study group on the improvement of nasal symptom-scores except for the rhinorrhea symptom-score. There were significant improvements in the quality of life domain after the treatment in the control group and the study group. However, there was no significant diference betwen the control and the study group on the improvement in quality of life domain except for activity limitations. Conclusion：A combination of pranlukast and cetirizine is as effective as a combination of pseudoephedrine and cetirizine in treating allergic tients who are not tolerable of pseudoephedrine.

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