Epilepsy and brain tumors

목차 (Table of Contents)

• CONTENTS
• Foreword = xi
• Preface = xiii
• Contributors = xv
• 1. Brain Tumor-Related Epilepsy : Introduction and Overview / MARTA MASCHIO, MD ; HERBERT B. NEWTON, MD, FAAN = 1
• Introduction = 1
• Epilepsy : Definition, Incidence, Social Context and Treatment Options = 2
• References = 8
• 2. Overview of Epidemiology, Pathology, and Treatment of Primary Brain Tumors / HERBERT B. NEWTON, MD, FAAN ; JOSE J. OTERO, MD, PhD = 11
• Epidemiology of PBT = 11
• Pathology of Selected PBT = 14
• Surgical Therapy of PBT = 20
• Radiation Therapy of PBT = 21
• Chemotherapy of PBT = 21
• Molecular or "Targeted" Treatment = 24
• Acknowledgments = 25
• References = 25
• 3. Overview of Epidemiology, Pathology, and Treatment of Metastatic Brain Tumors / HERBERT B. NEWTON, MD, FAAN ; JOSE J. OTERO, MD, PhD = 29
• Epidemiology of MBTs = 29
• Pathology of MBTs = 31
• Surgical Therapy of MBTs = 32
• Radiation Therapy of MBTs = 35
• Chemotherapy of MBTs = 37
• Acknowledgments = 39
• References = 39
• 4. Supportive Care of Brain Tumor Patients / HERBERT B. NEWTON, MD, FAAN ; LESLIE RAY, PharmD, BCOP = 45
• Introduction = 45
• Seizures and Anticonvulsant Therapy = 46
• Corticosteroids = 48
• Gastric Acid Inhibitors = 50
• Thromboembolic Complications and Anticoagulation = 50
• Dysphagia and Swallowing Disorders = 51
• Psychiatric Issues = 52
• Pain Control Issues = 56
• Palliative Care = 57
• Ethical Issues = 59
• Conclusion = 61
• References = 61
• 5. Brain-Tumor-Related Epilepsy in Children / JONATHAN LOPEZ, MD = 65
• The Pediatric Perspective = 65
• Epilepsy-Associated Brain Tumors = 65
• Pathophysiology = 67
• Epidemiology = 69
• Presentation = 70
• General Principles of Management = 74
• History and Physical Exam = 74
• Diagnostic Evaluation = 75
• Medical Management = 80
• Surgical Management = 85
• Outcome = 88
• Future Directions = 89
• Acknowledgment = 90
• References = 90
• 6. Mechanisms of Focal Epileptogenesis / MARCO DE CURTIS, MD ; LAURA LIBRIZZI, PhD ; GIULIANO AVANZINI, MD = 101
• Time Course and Specificity of Acquired Epileptogenesis = 102
• References = 106
• 7. Pathophysiology of Brain Tumor-Related Epilepsy / ANDREA SALMAGGI, MD ; TIZIANA GRANATA, MD ; ANDREA RIGAMONTI, MD = 111
• Introduction = 111
• Epidemiology of BTRE = 111
• Pathophysiology of BTRE = 112
• Treatment of BTRE = 114
• References = 117
• 8. The Neurophysiology of Central Nervous System Tumors / JESSE W. MINDEL, MD ; HERBERT B. NEWTON, MD ; J. LAYNE MOORE, MD = 119
• Introduction = 119
• EEG Modalities and Applications = 120
• EEG Background Changes = 121
• Epileptiform Activity = 122
• Meningiomas = 124
• Generation of Abnormal Cerebral Activity = 131
• References = 131
• 9. Surgical Treatment for Epilepsy / AMMAR SHAIKHOUNI, MD, PhD ; MILIND DEOGAONKAR, MD ; ALI REZAI, MD = 133
• Introduction = 133
• Evaluation and Selection of the Surgical Candidate = 133
• Resection Procedures = 134
• Nonresective Techniques = 135
• Disconnection Surgeries = 136
• References = 139
• 10. Clinical Evaluation of Epilepsy in the Brain-Tumor Patient / HERBERT B. NEWTON, MD, FAAN ; MARTA MASCHIO, MD = 143
• Differential Diagnosis = 145
• Clinical History and Physical Examination = 149
• Neuroimaging Evaluation = 150
• Clinical and Electrophysiological Work-Up = 153
• Effects of Oncological Therapy on Brain Tumor-Related Epilepsy = 155
• Acknowledgments = 157
• References = 157
• 11. Antiepileptic Drugs : First Generation / SHERI COTTERMAN-HART, MD, PhD = 159
• Carbamazepine = 159
• Ethosuximide = 161
• Phenobarbital = 163
• Phenytoin = 165
• Primidone = 166
• Valproate = 167
• References = 168
• 12. Antiepileptic Drugs : Second and Third Generation / SHERI COTTERMAN-HART, MD, PhD = 171
• Introduction = 171
• Clobazam = 171
• Eslicarbazepine Acetate = 173
• Ezogabine／Retigabine = 177
• Felbamate = 177
• Gabapentin = 178
• Lacosamide = 179
• Lamotrigine = 180
• Levetiracetam = 181
• Oxcarbazepine = 183
• Perampanel = 184
• Pregabalin = 184
• Rufinamide = 185
• Tiagabine Hydrochloride = 186
• Topiramate = 187
• Vigabatrin = 188
• Zonisamide = 189
• References = 190
• 13. Antiepileptic Drugs and Brain Tumor Patients / LESLIE RAY, PharmD, BCOP ; MARTA MASCHIO, MD ; HERBERT B. NEWTON, MD, FAAN = 195
• Introduction = 195
• Pathophysiology = 195
• Type of Seizure = 196
• Treatment of Seizures = 196
• Levetiracetam = 198
• Oxcarbazepine = 200
• Lacosamide = 201
• Pregabalin = 202
• Topiramate = 203
• Zonisamide = 203
• Lamotrigine = 204
• Conclusion = 204
• References = 204
• 14. Clinical Approach to Brain Tumor-Related Epilepsy / MARTA MASCHIO, MD ; HERBERT B. NEWTON, MD, FAAN = 207
• Seizure Prophylaxis in Patients with BTRE = 207
• Is There a Best Practice for Seizure Treatment? = 211
• Clinical Approach to BTRE = 217
• Driving and BTRE = 217
• References = 218
• 15. Neuropsychology of BTRE / MARTA MASCHIO, MD ; LOREDANA DINAPOLI, PhD = 225
• Introduction = 225
• Overview of Neurocognitive Impairment in BT, Epilepsy, and BTRE = 226
• Neurocognitive Impairment in BTRE = 229
• Specific Cognitive Deficits in BT, Epilepsy, and BTRE = 229
• Overview of Neuropsychological Assessment Techniques for BT, Epilepsy, and BTRE = 230
• Psychological Issues in BT, Epilepsy, and BTRE = 232
• Sexual Disturbances in Patients with BT, Epilepsy and BTRE = 234
• QoL Assessment and Monitoring in BT, Epilepsy and BTRE = 235
• Conclusions = 237
• References = 237
• 16. Cognitive Rehabilitation in Patients with BTRE / MARTA MASCHIO, MD ; LOREDANA DINAPOLI, PhD = 243
• Introduction = 243
• Goals of Cognitive Rehabilitation = 244
• Treatment Modalities in BT = 245
• Treatment Modalities in Epilepsy = 246
• Treatment Modalities in BTRE = 247
• Pharmacological Approaches for Treatment of Cognitive Deficits = 247
• Caregivers Issues = 248
• Implications for Future Research in BTRE = 249
• References = 255
• 17. Social Cost of Brain Tumor-Related Epilepsy / MARTA MASCHIO, MD ; FRANCESCO PALADIN, MD = 257
• Introduction = 257
• Health Economic Reporting : Terminology and Aims = 258
• Health Economics : Funding Priorities = 260
• Epilepsy = 262
• Brain Tumor = 265
• Conclusion = 266
• References = 267
• Appendix = 269
• Index = 271