X線 照射가 白鼠 肝臟의 形態學的 變化에 미치는 影響에 關한 硏究 = A Study on the Effects of X-irradiation causing Morphological Changes of the Rat liver

다국어 초록 (Multilingual Abstract)

To investigate the effects if ionizing radiation on the hepatic tissue, various doses of X-ray(1,000 rads, 1,400 rads, 1,800 rads) were irradiated to the left upper quadrant of abdomen of rats(source-skin distance, 1m;field size 23X23mm), by means of linear accelerator.
At 1, 2, 3, and 4 weeks after single exposure to each dose, histological(hematoxylin-eosin) and histochemical(PAS, trichrome, and reticulin) stains for the left lobe of the liver. Then inflammatory cell index, fibrosis index, nuclear index, and vascular index were estimated in the hepatic tissue specimens.
The results were as follows.
1. dilatation and congestion of the hepatic sinusoids were the most prominent at 1 week after 1,400 and 1,800 rads-irradiated liver tissue.
2. Inflammatory cell indices were increased in all irradiated livers, in comparison with that of control. The increase was most prominent in 1,800 rads-irradiated group.
3. Fibrosis indices were progressively increased from 2 weeks after irradiation, but withour dose-dependency.
4. Nuclear indices were begun to increase at 2 weeks after 1,400 and 1,800 rads-irradiation. The increase was prominent at 3 and 4 weeks after irradiation.
5. Vascular indices were not changed during 3 weeks after irradiation, and the gradual increasing-pattern was noted.
From these results, one could finds out changes of the hepatic tissue exposed to ionizing radiation are dilatation and congestion of sinusoids as an early response, and increased fibrosis and nuclear poikilosis as subsequent resoponses. The early changes might be a part of general inflammatory reaction and autoimmune reaction resulting from early tissue damage, and the subsequent changes are secondary to vascular injury induced by radiation.