RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      KCI등재 SCIE SCOPUS

      A New Monoterpene Glycoside from the Roots of Paeonia lactiflora Increases the Differentiation of Osteoblastic MC3T3-E1 Cells

      한글로보기

      https://www.riss.kr/link?id=A104665748

      • 0

        상세조회
      • 0

        다운로드
      서지정보 열기
      • 내보내기
      • 내책장담기
      • 공유하기
      • 오류접수

      부가정보

      다국어 초록 (Multilingual Abstract)

      A new monoterpene glycoside, 6'-O-β-D-glucopyranosylalbiflorin (1), and four known compounds; albiflorin (2), 6'-O-benzoylalbiflorin (3), paeoniflorin (4) and benzoyl paeoniflorin (5), were isolated from the methanolic extract of the roots of Paeonia lactiflora Pall.. Their chemical structures were completely elucidated using a combination of 2D NMR techniques (COSY, HMQC and HMBC) and HRESI-MS analyses. To investigate the bioactivities of these compounds, their effects on the differentiation of osteoblastic MC3T3-E1 cells were tested.
      Compound 1 (0.01-10 µM) significantly increased the alkaline phosphatase activity and nodules mineralization of MC3T3-E1 cells compared to those of the control (P<0.05). These results suggest that newly isolated compound 1 has a direct stimulatory effect on bone formation in vitro and may contribute to the prevention for osteoporosis.
      번역하기

      A new monoterpene glycoside, 6'-O-β-D-glucopyranosylalbiflorin (1), and four known compounds; albiflorin (2), 6'-O-benzoylalbiflorin (3), paeoniflorin (4) and benzoyl paeoniflorin (5), were isolated from the methanolic extract of the roots of Paeonia...

      A new monoterpene glycoside, 6'-O-β-D-glucopyranosylalbiflorin (1), and four known compounds; albiflorin (2), 6'-O-benzoylalbiflorin (3), paeoniflorin (4) and benzoyl paeoniflorin (5), were isolated from the methanolic extract of the roots of Paeonia lactiflora Pall.. Their chemical structures were completely elucidated using a combination of 2D NMR techniques (COSY, HMQC and HMBC) and HRESI-MS analyses. To investigate the bioactivities of these compounds, their effects on the differentiation of osteoblastic MC3T3-E1 cells were tested.
      Compound 1 (0.01-10 µM) significantly increased the alkaline phosphatase activity and nodules mineralization of MC3T3-E1 cells compared to those of the control (P<0.05). These results suggest that newly isolated compound 1 has a direct stimulatory effect on bone formation in vitro and may contribute to the prevention for osteoporosis.

      더보기

      참고문헌 (Reference)

      1 "The prevention and treatment of osteoporosis. N. Engl. J. Med. 327" 620-627, 1992

      2 "The medicinal plants and animals of Vietnam, Hanoi Science and Technology Publisher, 1 st edition" Hanoi 363-, 2004

      3 "Monoterpene glycosides from Paeoni suffruticosa" 41 : 237-242, 1996

      4 "Mono- terpenoid derivatives from Paeonia delavayi . J"

      5 "Initiation and progression of mineralization of bone nodules formed in vitro - The role of alkaline-phosphatase and organic phosphate. Bone and Miner." 27-40, 1991

      6 "In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J. Cell. Biol." 191-1981983

      7 "Comparison of bone formation responses to parathyroid hormone (1-34), (1-31), and (2-34) in mice" 27 : 471-478, 2000

      8 "Advances in bone biology: the osteoblast" 17 : 308-332, 1996

      9 "A monoter- pene glucoside from Paeonia peregrina roots" 47 : 1303-1307, 1998

      10 "A New Monoterpene Glycoside from the Roots of Paeonia lactiflora 1185 Kodama Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Jpn. J. Oral Biol." 899-901, 1981

      1 "The prevention and treatment of osteoporosis. N. Engl. J. Med. 327" 620-627, 1992

      2 "The medicinal plants and animals of Vietnam, Hanoi Science and Technology Publisher, 1 st edition" Hanoi 363-, 2004

      3 "Monoterpene glycosides from Paeoni suffruticosa" 41 : 237-242, 1996

      4 "Mono- terpenoid derivatives from Paeonia delavayi . J"

      5 "Initiation and progression of mineralization of bone nodules formed in vitro - The role of alkaline-phosphatase and organic phosphate. Bone and Miner." 27-40, 1991

      6 "In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J. Cell. Biol." 191-1981983

      7 "Comparison of bone formation responses to parathyroid hormone (1-34), (1-31), and (2-34) in mice" 27 : 471-478, 2000

      8 "Advances in bone biology: the osteoblast" 17 : 308-332, 1996

      9 "A monoter- pene glucoside from Paeonia peregrina roots" 47 : 1303-1307, 1998

      10 "A New Monoterpene Glycoside from the Roots of Paeonia lactiflora 1185 Kodama Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Jpn. J. Oral Biol." 899-901, 1981

      더보기

      분석정보

      View

      상세정보조회

      0

      Usage

      원문다운로드

      0

      대출신청

      0

      복사신청

      0

      EDDS신청

      0

      동일 주제 내 활용도 TOP

      더보기

      주제

      연도별 연구동향

      연도별 활용동향

      연관논문

      연구자 네트워크맵

      공동연구자 (7)

      유사연구자 (20) 활용도상위20명

      인용정보 인용지수 설명보기

      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2001-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1998-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
      더보기

      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.96 0.2 1.44
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.07 0.87 0.439 0.05
      더보기

      이 자료와 함께 이용한 RISS 자료

      나만을 위한 추천자료

      해외이동버튼