Antiulcerogenic effects of Gymnosporia rothiana

다국어 초록 (Multilingual Abstract)

Gymnosporia rothiana (walp) Lawson (celastraceae), commonly known as Maytenus rothiana, is
used in Indian folk medicine as an antiulcerogenic agent. However, there have been no scientific
reports regarding its antiulcer activity. Therefore, this study was intended to evaluate the antiulcer
property of petroleum ether, chloroform, and methanolic extract of leaves of Gymnosporia rothiana
at different dose levels in ethanol induced and indomethacin induced gastric ulcer models. It was
observed that oral administration of all the extract of Gymnosporia rothiana produces significant
reduction in ulcer lesion index as well as increase in volume and pH of gastric content in both
experimental models, being petroleum ether extract the most effective at dose of 250 mg/kg; it
significantly reduced gastric lesion index (70.06%), in comparison to omeprazole (71.20%) and
methanolic extract at a dose of 500 mg/kg (67.22%). Increased gastric mucosal defense mechanism by
petroleum ether extract is probably due to its high levels of terpenoids like β amyrin, lupeol
acetate. The present results clearly shows antiulcer effect of Gymnosporia rothiana against various
irritants has been mainly due to cytoprotective effect mediated through prostaglandin and partly
due to free radical scavenging activity.

다국어 초록 (Multilingual Abstract)

Gymnosporia rothiana (walp) Lawson (celastraceae), commonly known as Maytenus rothiana, is
used in Indian folk medicine as an antiulcerogenic agent. However, there have been no scientific
reports regarding its antiulcer activity. Therefore, this study was intended to evaluate the antiulcer
property of petroleum ether, chloroform, and methanolic extract of leaves of Gymnosporia rothiana
at different dose levels in ethanol induced and indomethacin induced gastric ulcer models. It was
observed that oral administration of all the extract of Gymnosporia rothiana produces significant
reduction in ulcer lesion index as well as increase in volume and pH of gastric content in both
experimental models, being petroleum ether extract the most effective at dose of 250 mg/kg; it
significantly reduced gastric lesion index (70.06%), in comparison to omeprazole (71.20%) and
methanolic extract at a dose of 500 mg/kg (67.22%). Increased gastric mucosal defense mechanism by
petroleum ether extract is probably due to its high levels of terpenoids like β amyrin, lupeol
acetate. The present results clearly shows antiulcer effect of Gymnosporia rothiana against various
irritants has been mainly due to cytoprotective effect mediated through prostaglandin and partly
due to free radical scavenging activity.

참고문헌 (Reference)

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