Heterogeneous living donor hepatic fat distribution on MRI chemical shift imaging

다국어 초록 (Multilingual Abstract)

Purpose: We evaluated the heterogeneity of steatosis in living donor livers to determine its regional differences.
Methods: Between June 2011 and February 2012, 81 liver donors were selected. Fat fraction was estimated using magnetic resonance triple-echo chemical shifting gradient imaging in 13 different regions: segment 1 (S1), S2, S3, and each peripheral and deep region of S4, S5, S6, S7, and S8.
Results: There were differences (range, 3.2%?5.3%) in fat fractions between each peripheral and deep region of S4, S6, S7, and S8 (P < 0.001, P = 0.004, P < 0.001, and P = 0.006). Fat deposit amount in S1, S2, S3 and deep regions of S4?S8 were significantly different from one another (F [4.003, 58.032] = 8.684, P < 0.001), while there were no differences among the peripheral regions of S4-S8 (F [2.9, 5.3] = 1.3, P = 0.272) by repeated measure analysis of variance method. And regional differences of the amount of fat deposit in the whole liver increased as a peripheral fat fraction of S5 increased (R² = 0.428, P < 0.001).
Conclusion: Multifocal fat measurements for the whole liver are needed because a small regional evaluation might not represent the remaining liver completely, especially in patients with severe hepatic steatosis.

목차 (Table of Contents)

• INTRODUCTION
• METHODS
• RESULTS
• DISCUSSION
• REFERENCES

참고문헌 (Reference)

1 Lee SW., "Unenhanced CT for assessment of macrovesicular hepatic steatosis in living liver donors : comparison of visual grading with liver attenuation index" 244 : 479-485, 2007

2 Cho JY., "The hepatic regeneration power of mild steatotic grafts is not impaired in living-donor liver transplantation" 11 : 210-217, 2005

3 Ratziu V., "Sampling variability of liver biopsy in nonalcoholic fatty liver disease" 128 : 1898-1906, 2005

4 Peng XG., "Quantification of liver fat in mice : comparing dual-echo Dixon imaging, chemical shift imaging, and 1H-MR spectroscopy" 52 : 1847-1855, 2011

5 Guiu B., "Quantification of liver fat content : comparison of tripleecho chemical shift gradient-echo imaging and in vivo proton MR spectroscopy" 250 : 95-102, 2009

6 Meisamy S., "Quantification of hepatic steatosis with T1independent, T2-corrected MR imaging with spectral modeling of fat : blinded comparison with MR spectroscopy" 258 : 767-775, 2011

7 Joe E., "Quantification of hepatic macrosteatosis in living, related liver donors using T1-independent, T2*-corrected chemical shift MRI" 36 : 1124-1130, 2012

8 Schwimmer JB., "Prevalence of fatty liver in children and adolescents" 118 : 1388-1393, 2006

9 Wieckowska A., "Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis : present and future" 46 : 582-589, 2007

10 Lee SS., "Non-invasive assessment of hepatic steatosis : prospective comparison of the accuracy of imaging examinations" 52 : 579-585, 2010

11 Park SH., "Macrovesicular hepatic steatosis in living liver donors : use of CT for quantitative and qualitative assessment" 239 : 105-112, 2006

12 Ma X., "Imaging-based quantification of hepatic fat : methods and clinical applications" 29 : 1253-1277, 2009

13 Kim SH., "Hepatic macrosteatosis : predicting appropriateness of liver donation by using MR imaging : correlation with histopathologic findings" 240 : 116-129, 2006

14 Kang BK., "Hepatic fat quantification : a prospective comparison of magnetic resonance spectroscopy and analysis methods for chemical-shift gradient echo magnetic resonance imaging with histologic assessment as the reference standard" 47 : 368-375, 2012

15 Bashir MR., "Hepatic MR imaging for in vivo differentiation of steatosis, iron deposition and combined storage disorder: single-ratio in/opposed phase analysis vs. dual-ratio Dixon discrimination" 81 : e101-9-, 2012

16 Hamer OW., "Fatty liver : imaging patterns and pitfalls" 26 : 1637-1653, 2006

17 Henninger B., "Evaluation of liver fat in the presence of iron with MRI using T2* correction : a clinical approach" 23 : 1643-1649, 2013

18 Adam R., "Effect of extended cold ischaemia with UW solution on graft function after liver transplantation" 340 : 1373-1376, 1992

19 Ishizaka K., "Comparison of 1H MR spectroscopy, 3-point DIXON, and multi-echo gradient echo for measuring hepatic fat fraction" 10 : 41-48, 2011

20 Hatta T., "Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging : a prospective study in biopsy-proven nonalcoholic fatty liver disease" 45 : 1263-1271, 2010