Antimelanogenic chemicals with in vivo efficacy against skin pigmentation in guinea pigs

다국어 초록 (Multilingual Abstract)

Ultraviolet (UV) radiation under sunlightstimulates skin pigmentation through immediately affectingthe oxidative modification of existing melanin pigmentsand the spatial redistribution of pigmentedmelanosomes followed by the up-regulation of melanogenicgenes in delayed kinetics. However, abnormalaccumulation and synthesis of melanin biopolymers areresponsible for skin disorders with more pigmented patches.
Chemical-based regulation of the hyperpigmenteddisorders has been a long-standing goal for cosmetic andpharmaceutical applications. A large number of thechemicals with antimelanogenic activity have met withlimited or no success in the treatment of skin patients, sincethey may not overcome the challenge of penetrating theskin barrier. Guinea pig skin displays similar kineticparameters to human skin in the transdermal absorption ofnumerous chemicals, thus can serve as the surrogate forhuman skin. Here, we provide a concise review of ourcurrent understanding of the chemical-based therapyagainst skin hyperpigmentation in UV-irradiated guineapig models, suggest molecular mechanisms of the actionand emphasize the translation from preclinical outcomes toskin patients.

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