유리체강내 간시클로버와 포스카네트 병합 치료로 호전된 진행성외망막괴사 1예

다국어 초록 (Multilingual Abstract)

Purpose: To report a case of progressive outer retinal necrosis treated by combined intravitreal foscarnet and ganciclovir.
Case summary: A 11-year-old male with a history of chemotherapy and cord blood transplantation due to precursor T-cell leukemia developed Herpes zoster lesion on his forehead and rapidly progressing peripheral retinal necrosis without vasculitis in the right eye. Varicella-Zoster virus was confirmed in his cerebrospinal fluid using polymerase chain reaction (PCR); and the patient was diagnosed with progressive outer retinal necrosis. Despite combined treatment with intravenous acyclovir and foscarnet and intravitreal foscarnet, retinal necrosis progressed to retinal detachment and total retinal necrosis. During follow-up, new retinal necrosis was observed in his left eye. The patient was started on combined intravenous and intravitreal foscarnet and ganciclovir;
retinal necrosis in the left eye regressed and posterior pole was spared. With subsequent oral valganciclovir and intravitreal foscarnet and ganciclovir, the remaining retina was preserved with maintained vision.

참고문헌 (Reference)

1 Margolis TP., "Varicella-zoster virus retinitis in patients with the acquired immunodeficiency syndrome" 112 : 119-131, 1991

2 Friedman SM., "Varicella-zoster virus retinitis as the initial manifestation of the acquired immunodeficiency syndrome" 117 : 536-538, 1994

3 Engstrom RE Jr., "The progressive outer retinal necrosis syndrome. A variant of necrotizing herpetic retinopathy in patients with AIDS" 101 : 1488-1502, 1994

4 Ciulla TA., "The progressive outer retinal necrosis syndrome : successful treatment with combination antiviral therapy" 29 : 198-206, 1998

5 Teich SA., "Systemic antiviral drugs used in ophthalmology" 37 : 19-53, 1992

6 Spaide RF., "Successful treatment of progressive outer retinal necrosis syndrome" 16 : 479-487, 1996

7 Holland GN., "Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society" 117 : 663-667, 1994

8 Chung H., "Retinal complications in patients with solid organ or bone marrow transplantations" 83 : 694-699, 2007

9 Forster DJ., "Rapidly progressive outer retinal necrosis in the acquired immunodeficiency syndrome" 110 : 341-348, 1990

10 Bryan RG., "Progressive outer retinal necrosis in a patient with rheumatoid arthritis" 116 : 1249-, 1998

11 Njoo FL., "Progressive outer retinal necrosis in a patient with cutaneous non-Hodgkin's T cell lymphoma(Sézary syndrome)" 82 : 1218-1219, 1998

12 Doi M., "Progressive outer retinal necrosis in a human immunodeficiency virus-negative patient" 19 : 468-470, 1999

13 Lewis JM., "Progressive outer retinal necrosis after bone marrow transplantation" 122 : 892-895, 1996

14 Gore DM., "Progressive outer retinal necrosis : outcomes in the intravitreal era" 130 : 700-706, 2012

15 Marin M., "Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP)" 56 (56): 1-40, 2007

16 Gershon AA., "Perspectives on vaccines against varicella-zoster virus infections" 342 : 359-372, 2010

17 김상진, "Ocular Manifestations of Acquired Immunodeficiency Syndrome in Korea" 대한의학회 27 (27): 542-546, 2012

18 Guex-Crosier Y., "Necrotizing herpetic retinopathies. A spectrum of herpes virus-induced diseases determined by the immune state of the host" 5 : 259-265, 1997

19 Moorthy RS., "Management of varicella zoster virus retinitis in AIDS" 81 : 189-194, 1997

20 López-Cortés LF., "Intravitreal pharmacokinetics and retinal concentrations of ganciclovir and foscarnet after intravitreal administration in rabbits" 42 : 1024-1028, 2001

21 Scott IU., "Intravitreal antivirals in the management of patients with acquired immunodeficiency syndrome with progressive outer retinal necrosis" 120 : 1219-1222, 2002

22 Field HJ., "Herpes simplex virus antiviral drug resistance-current trends and future prospects" 21 : 261-269, 2001

23 Jacobson MA., "Foscarnet treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome" 33 : 736-741, 1989

24 Hegazy HM., "Evaluation of toxicity of intravitreal ceftazidime, vancomycin, and ganciclovir in a silicone oil-filled eye" 19 : 553-557, 1999