한국인에서 커피 및 녹차의 섭취빈도가 간염증 수치 및 대사증후군에 미치는 영향

국문 초록 (Abstract)

본 연구의 목적은 한국에서 커피 및 녹차 등을 섭취하는 생활습관이 혈청 AST, ALT 및 대사증후군에 미치 는 영향에 대하여 알아보고자 하였다. 국민건강영양조사를 받은 모든 연령의 약 4만 8천명 중 19세부터 79세의 성인 남녀를 대상으로 하였다. 지난 1년간 흡연, 음주력의 여부, 1개월 간 흡연양, 알코올 섭취량, 체중, 체질량지수, 중성 지방, 고밀도 지단백, 혈청 AST, ALT를 측정을 하였고 이를 바탕으로 대사성 증후군을 평가하였다. 커피를 많이 마 실수록 통계적으로 유의하게 체중(p≤0.001)과 체질량 지수(p≤0.001)는 높았다. 커피를 많이 마시는 사람에서 혈청 AST는 낮았다(p=0.017). 하루에 커피를 한잔 이상 섭취하는 경우 고혈압의 유병률, 공복혈당 이상 및 고지혈증의 빈 도가 낮았으며, 대사증후군의 발생빈도가 의미 있게 낮았다. 녹차 섭취 빈도 증가는 혈청 AST, ALT 에 영향을 미치 지 않았다. 녹차를 많이 마시는 것과 체질량지수, 대사성 증후군의 유병률과는 연관이 없었다. 결론적으로 커피 섭취 를 많이 마시는 사람에서 혈청 AST수치가 낮았다. 커피를 하루에 두잔 이상 섭취하는 군에서 총에너지 섭취와 체질 량 지수가 높았으나 고혈압, 고지혈증, 공복혈당이 의미 있게 낮았으며 대사증후군의 발생률도 낮았다.

다국어 초록 (Multilingual Abstract)

We investigated whether coffee and green tea consumption reduced the risk of elevated alanine aminotransferase(ALT) / aspartate aminotransferase(AST) activity and the prevalence of metabolic syndrome. Participants were 5,283 adults, aged 19 –79 years, in the Third Korean National Health and Nutrition Examination Survey, with excessive alcohol consumption, overweight, viral hepatitis, metabolic syndrome. Increased coffee and green tea consumption was not associated with decreased serum ALT. However, amount of coffee consumption had negative correlation with serum AST activity. Moreover, coffee consumption reduced the prevalence of metabolic syndrome (p for trend <0.001). Hypertension, impaired glucose metabolism and dyslipidemia was involved as subgroup of metabolic syndrome. Comparing persons who drank more than 2 cups per day with less than 1 cup per day, the prevalence of all subgroups was declined significantly. In this large, national, population-based study, consumption of coffee was associated with lower the risk of metabolic syndrome.

참고문헌 (Reference)

1 G. Vernon, "Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults" 274-285, 2011

2 R. Urgert, "Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases" 519-524, 1997

3 A. J. Sanyal, "Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis" 1675-1185, 2010

4 D. A. Sass, "Nonalcoholic fatty liver disease: a clinical review" 171-180, 2005

5 E. R. Miller, "Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality" 37-46, 2005

6 V. Ratziu, "Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial" 445-453, 2010

7 Y. Kawamura, "Large-scale long-term follow-up study of Japanese patients with non-alcoholic Fatty liver disease for the onset of hepatocellular carcinoma" 253-261, 2012

8 D. Catalano, "Insulin resistance in postmenopausal women: concurrent effects of hormone replacement therapy and coffee" 373-382, 2008

9 S. Sullivan, "Implications of diet on nonalcoholic fatty liver disease" 160-164, 2010

10 M. P. Weusten-Van der Wouw, "Identity of the cholesterol-raising factor from boiled coffee and its effects on liver function enzymes" 721-733, 1994

11 A. Hino A, "Habitual coffee but not green tea consumption is inversely associated with metabolic syndrome: an epidemiological study in a general Japanese population" 383-389, 2007

12 B. B. Merriman, "Genetic influences in nonalcoholic fatty liver disease" (Suppl 1) : S30-S33, 2006

13 D. S. Pratt, "Evaluation of abnormal liver-enzyme results in asymptomatic patients" 1266-1271, 2000

14 R. Urgert, "Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in humans" 149-154, 1999

15 S. Honjo, "Coffee drinking and serum gamma-glutamyltransferase: an extended study of Self-Defense Officials of Japan" 325-331, 1999

16 S. Honjo, "Coffee consumption and serum aminotransferases in middle-aged Japanese men" 823-829, 2001

17 K. Tanaka, "Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers" 438-443, 1998

18 S. Kono, "Coffee and serum gammaglutamyltransferase: a study of self-defense officials in Japan" 723-727, 1994

19 C. E. Ruhl, "Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States" 24-32, 2005

20 O. W. Kwon, "Carbohydrate but not fat is associated with elevated aminotransferases" 1365-2036, 2012

21 전대원, "A study of the awareness of chronic liver diseases among Korean adults" 대한간학회 17 (17): 99-105, 2011

22 J. van Rooij, "A placebo-controlled parallel study of the effect of two types of coffee oil on serum lipids and transaminases: identification of chemical substances involved in the cholesterol-raising effect of coffee" 1277-1283, 1995